Combination of Atrial Fibrillation and Coronary Heart Disease in Patients in Clinical Practice: Comorbidities, Pharmacotherapy and Outcomes (Data from the REСVASA Registries)
| Autor: | S. Yu. Martsevich, E. V. Kudryashov, M. M. Loukianov, T. A. Gomova, Е. Yu. Okshina, V. V. Yakusevich, V. G. Klyashtorny, V. P. Mikhin, A. V. Zagrebelny, Oxana Drapkina, E. N. Belova, E. Yu. Andrenko, A. N. Makoveeva, K. G. Pereverzeva, M. M. Valiakhmetov, Sergey Boytsov, Ju. E. Tatsii, S. S. Yakushin, A. N. Vorobiev, Yu. V. Maslennikova, E. M. Pozdnyakova, E. E. Fedotova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
multimorbidity RM1-950 outcomes Coronary artery disease pharmacotherapy Internal medicine Diabetes mellitus medicine Diseases of the circulatory (Cardiovascular) system atrial fibrillation Pharmacology (medical) Myocardial infarction outpatient and hospital registries business.industry Incidence (epidemiology) Atrial fibrillation medicine.disease mortality myocardial infarction RC666-701 Relative risk Heart failure Cardiology Therapeutics. Pharmacology Cardiology and Cardiovascular Medicine business coronary artery disease concomitant diseases Kidney disease |
| Zdroj: | Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 17, Iss 5, Pp 702-711 (2021) |
| ISSN: | 2225-3653 1819-6446 |
| Popis: | Aim. Assess the structure of comorbid conditions, cardiovascular pharmacotherapy and outcomes in patients with atrial fibrillation (AF) and concomitant coronary artery disease (CAD) included in the outpatient and hospital RECVASA registries.Materials and methods. 3169 patients with AF were enrolled in outpatient RECVASA (Ryazan), RECVASA AF-Yaroslavl registries and hospital RECVASA AF (Moscow, Kursk, Tula). 2497 (78.8%) registries of patients with AF had CAD and 703 (28.2%) of them had a previous myocardial infarction (MI).Results. There were 2,497 patients with a combination of AF and CAD (age was 72.2±9.9 years; 43.1% of men; CHA2DS2-VASc – 4.57±1.61 points; HAS-BLED – 1.60±0,75 points), and the group with AF without CAD included 672 patients (age was 66.0±12.3 years; 43.2% of men; CHA2DS2-VASc – 3.26±1.67 points; HAS-BLED – 1,11±0.74 points). Patients with CAD were on average 6.2 years older and had a higher risk of thromboembolic and hemorrhagic complications (pConclusion. 78.8% of patients from AF registries in 5 regions of Russia were diagnosed with CAD, of which 28.2% had previously suffered myocardial infarction. Patients with a combination of AF and CAD more often than in the absence of CAD had hypertension, chronic heart failure, diabetes, chronic kidney disease and anemia. Patients with the previous MI had higher incidence of diabetes than those without the previous MI. The frequency of proper cardiovascular pharmacotherapy was insufficient, and to a greater extent in the presence of CAD and the previous MI than in their absence. All-cause mortality was recorded in patients with a combination of AF and CAD more often than in the absence of CAD. All-cause mortality and the incidence of nonfatal myocardial infarction were higher in patients with AF and the previous MI than in those without the previous MI. The presence of CAD and, in particular, the previous MI, was significantly associated with a higher risk of death, as well as a higher risk of developing a combined cardiovascular endpoint. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|