Comprehensive Characterization of the Major Presynaptic Elements to the Drosophila OFF Motion Detector
| Autor: | Matthias Meier, Aljoscha Leonhardt, Etienne Serbe, Alexander Borst |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Brightness Sensory Receptor Cells Neuroscience(all) CD8 Antigens Green Fluorescent Proteins Motion Perception Presynaptic Terminals Action Potentials Biology Motion (physics) Animals Genetically Modified 03 medical and health sciences Calcium imaging Animals Visual Pathways Neurons Motion detector General Neuroscience Functional specialization Motion detection Expression (mathematics) Characterization (materials science) Microscopy Electron 030104 developmental biology Calcium Drosophila Visual Fields Biological system Neuroscience Algorithms |
| Zdroj: | Neuron. 89:829-841 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2016.01.006 |
| Popis: | Estimating motion is a fundamental task for the visual system of sighted animals. In Drosophila, direction-selective T4 and T5 cells respond to moving brightness increments (ON) and decrements (OFF), respectively. Current algorithmic models of the circuit are based on the interaction of two differentially filtered signals. However, electron microscopy studies have shown that T5 cells receive their major input from four classes of neurons: Tm1, Tm2, Tm4, and Tm9. Using two-photon calcium imaging, we demonstrate that T5 is the first direction-selective stage within the OFF pathway. The four cells provide an array of spatiotemporal filters to T5. Silencing their synaptic output in various combinations, we find that all input elements are involved in OFF motion detection to varying degrees. Our comprehensive survey challenges the simplified view of how neural systems compute the direction of motion and suggests that an intricate interplay of many signals results in direction selectivity. |
| Databáze: | OpenAIRE |
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