Prednisolone Pretreatment Enhances Intermittent Hypoxia-Induced Plasticity in Persons With Chronic Incomplete Spinal Cord Injury
| Autor: | Milap S. Sandhu, Arun Jayaraman, Masha Kocherginsky, William Z. Rymer, Gordon S. Mitchell, Elizabeth Gray |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.drug_class Prednisolone Anti-Inflammatory Agents Inflammation Placebo 03 medical and health sciences 0302 clinical medicine Double-Blind Method immune system diseases Fraction of inspired oxygen Medicine Humans Hypoxia Spinal cord injury Spinal Cord Injuries 030304 developmental biology 0303 health sciences Cross-Over Studies Neuronal Plasticity business.industry Electromyography Neurological Rehabilitation Intermittent hypoxia General Medicine Middle Aged medicine.disease digestive system diseases medicine.anatomical_structure Treatment Outcome Anesthesia Chronic Disease Corticosteroid Female Ankle medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurorehabilitation and neural repair. 33(11) |
| ISSN: | 1552-6844 |
| Popis: | Objective. To test the hypothesis that an anti-inflammatory corticosteroid drug enhances spinal motor plasticity induced by acute intermittent hypoxia (AIH) in persons with chronic incomplete spinal cord injury (iSCI). Methods. Fourteen subjects with incomplete spinal cord injury (ASIA level C or D; mean age = 46 years) participated in a randomized, double-blinded, crossover, and placebo-controlled study. Subjects received either 60 mg oral prednisolone or a matching placebo, 1 hour before administration of AIH (15, 60-second hypoxic exposures; fraction of inspired oxygen [FiO2] = 0.09). Changes in voluntary ankle strength, lower extremity electromyograms (EMG), and serum inflammatory biomarkers were quantified. Results. Maximal ankle plantarflexion torque was significantly higher following prednisolone + AIH versus placebo + AIH (mean difference [MD] 9, 11, and 7 newton meter [N∙m] at 30, 60, and 120 minutes post-AIH, respectively; all Ps |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|