Novel human metapneumovirus with a 180-nucleotide duplication in the G gene
| Autor: | Pilar Alcubilla, Jorgina Vila, Cristina Andrés, Rosario Saiz, Laura Gimferrer, Carlos Rodrigo, Mercedes Martín, Francisco Fuentes, Maria Gema Codina, María Valls, Javier Ramón, Tomás Pumarola, Maria Piñana, Andrés Antón |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) Genotype viruses Microbiology Viral Proteins 03 medical and health sciences Human metapneumovirus Gene duplication Prevalence Humans Child Respiratory Tract Infections Phylogeny Glycoproteins Genetics Genetic diversity Paramyxoviridae Infections Molecular epidemiology biology Phylogenetic tree Nucleotides Genetic Variation Infant Sequence Analysis DNA biology.organism_classification Virology 030104 developmental biology Spain Epidemiological Monitoring RNA Viral Respiratory virus Female Metapneumovirus |
| Zdroj: | Future Microbiology. 12:565-571 |
| ISSN: | 1746-0921 1746-0913 |
| DOI: | 10.2217/fmb-2016-0211 |
| Popis: | Aim: To describe the circulation, genetic diversity and clinical features of human metapneumovirus (HMPV) in pediatric patients that attended the Hospital Universitari Vall d'Hebron, Spain from 2014 to 2016. Materials & methods: Partial G gene was sequenced from laboratory-confirmed HMPV respiratory specimens for subsequent phylogenetic analysis. Results: A total of 121 different samples were HMPV laboratory-confirmed out of 6658 specimens received. The highest circulation was from February to April, with a prevalence of 3%. Different genetic groups within both genotypes were detected at variable levels. A 180-nucleotide duplication was first characterized within the G gene in nine cases, mostly related to lower respiratory-tract infection. Conclusion: This study reported on the circulation of a novel HMPV with a 180-nucleotide duplication in the G gene, but no clinical changes in related cases were observed. Their prevalence increased during the last season suggesting changes in viral features. |
| Databáze: | OpenAIRE |
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