Lipid-hyaluronan synergy strongly reduces intrasynovial tissue boundary friction
| Autor: | Ronit Goldberg, Oleg Dolkart, Reut Mashiah, Jasmine Seror, Tamir Pritsch, Weifeng Lin, Jacob Klein, Assaf Kadar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Cartilage
Articular musculoskeletal diseases Friction 0206 medical engineering Biomedical Engineering Context (language use) 02 engineering and technology Osteoarthritis Biochemistry Boundary friction Avian Proteins Biomaterials chemistry.chemical_compound Lubricity Lubrication Synovial Fluid Hyaluronic acid medicine Animals Humans Hyaluronic Acid Molecular Biology Synovial joints Glycoproteins Chemistry General Medicine Lipid Metabolism musculoskeletal system 021001 nanoscience & nanotechnology medicine.disease Lipids 020601 biomedical engineering Tendon medicine.anatomical_structure Biophysics Aluminum Silicates 0210 nano-technology Chickens Biotechnology |
| Zdroj: | Acta Biomaterialia |
| ISSN: | 1742-7061 |
| Popis: | Hyaluronan (HA)-lipid layers on model (mica) surfaces massively reduce friction as the surfaces slide past each other, and have been proposed, together with lubricin, as the boundary layers accounting for the extreme lubrication of articular cartilage. The ability of such HA-lipid complexes to lubricate sliding biological tissues has not however been demonstrated. Here we show that HA-lipid layers on the surface of an intrasynovial tendon can strongly reduce the friction as the tendon slides within its sheath. We find a marked lubrication synergy when combining both HA and lipids at the tendon surface, relative to each component alone, further enhanced when the polysaccharide is functionalized to attach specifically to the tissue. Our results shed light on the lubricity of sliding biological tissues, and indicate a novel approach for lubricating surfaces such as tendons and, possibly, articular cartilage, important, respectively, for alleviating function impairment following tendon injury and repair, or in the context of osteoarthritis. STATEMENT OF SIGNIFICANCE: Lubrication breakdown between sliding biological tissues is responsible for pathologies ranging from dry eye syndrome to tendon-injury repair impairment and osteoarthritis. These are increasing with human longevity and impose a huge economic and societal burden. Here we show that synergy of hyaluronan and lipids, molecules which are central components of synovial joints and of the tendon/sheath system, can strongly reduce friction between sliding biological tissues (the extrasynovial tendon sliding in its sheath), relative to untreated tissue or to either component on its own. Our results point to the molecular origins of the very low friction in healthy tendons and synovial joints, as well as to novel treatments of lubrication breakdown in these organs. |
| Databáze: | OpenAIRE |
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