Extracellular vesicles from human bone marrow mesenchymal stem cells repair organ damage caused by cadmium poisoning in a medaka model
| Autor: | Esther A. Weygant, Hiroyuki Matsumoto, Deborah Hyink, Tomoko Obara, Daiki Kitamura, Tomomi Matsukura, Shosaku Kashiwada, Chisako Inaba, Ralf Janknecht |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cadmium Poisoning
Physiology cadmium Cell Oryzias Bone Marrow Cells 030204 cardiovascular system & hematology Mesenchymal Stem Cell Transplantation lcsh:Physiology Cadmium poisoning Kidney Tubules Proximal 03 medical and health sciences Extracellular Vesicles 0302 clinical medicine Physiology (medical) medicine Animals Humans Bone Cell damage Cells Cultured Original Research Kidney medaka mesenchymal stem cells lcsh:QP1-981 business.industry Podocytes Mesenchymal stem cell Environmental exposure medicine.disease Mitochondria medicine.anatomical_structure Cancer research Stem cell business 030217 neurology & neurosurgery chronic kidney disease Kidney disease |
| Zdroj: | Physiological Reports Physiological Reports, Vol 7, Iss 14, Pp n/a-n/a (2019) |
| ISSN: | 2051-817X |
| Popis: | Treatment modalities for kidney disease caused by long‐term exposure to heavy metals, such as cadmium (Cd), are limited. Often, chronic, long‐term environmental exposure to heavy metal is not recognized in the early stages; therefore, chelation therapy is not an effective option. Extracellular vesicles (EVs) derived from stem cells have been demonstrated to reduce disease pathology in both acute and chronic kidney disease models. To test the ability of EVs derived from human bone marrow mesenchymal stem cells (hBM‐MSCs) to treat Cd damage, we generated a Cd‐exposed medaka model. This model develops heavy metal‐induced cell damage in various organs and tissues, and shows decreased overall survival. Intravenous injection of highly purified EVs from hBM‐MSCs repaired the damage to apical and basolateral membranes and mitochondria of kidney proximal tubules, glomerular podocytes, bone deformation, and improved survival. Our system also serves as a model with which to study age‐ and sex‐dependent cell injuries of organs caused by various agents and diseases. The beneficial effects of EVs on the tissue repair process, as shown in our novel Cd‐exposed medaka model, may open new broad avenues for interventional strategies. |
| Databáze: | OpenAIRE |
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