Recurrence of duodenal ulcer afterHelicobacter pylorieradication is related to high acid output
| Autor: | M. R. Jacyna, P. A. Gummett, A W Harris, P. S. Phull, J. H. Baron, J. J. Misiewicz |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Spirillaceae macromolecular substances Gastroenterology Helicobacter Infections Gastric Acid Pathogenesis Basal (phylogenetics) Recurrence Internal medicine medicine Humans Pharmacology (medical) Chemotherapy Helicobacter pylori Hepatology biology business.industry Stomach Middle Aged bacterial infections and mycoses biology.organism_classification digestive system diseases Pentagastrin medicine.anatomical_structure Gastrin-Releasing Peptide Duodenal Ulcer Duodenum Peptides business medicine.drug |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 11:331-334 |
| ISSN: | 0269-2813 |
| DOI: | 10.1046/j.1365-2036.1997.146322000.x |
| Popis: | Helicobacter pylori eradication reduces the recurrence of duodenal ulcers. It is unclear why duodenal ulcers rarely recur in the absence of reinfection with H. pylori or NSAID treatment.Basal, gastrin-releasing peptide- and pentagastrin-stimulated peak acid outputs in patients with ulcer relapse after H. pylori eradication were measured, and compared with patients without ulcer relapse after H. pylori eradication.Pentagastrin-stimulated peak acid output was significantly higher in H. pylori-positive patients with duodenal ulcers than in H. pylori-negative controls, and fell significantly after H. pylori eradication. In H. pylori-negative patients with recurrent duodenal ulcers, pentagastrin-stimulated peak acid output was significantly higher than in controls and similar to H. pylori-positive patients with duodenal ulcers.These findings suggest that duodenal ulcer relapse after eradication of H. pylori may be related to high pentagastrin-stimulated peak acid output. In this subset of patients with duodenal ulcers, maintenance anti-secretory treatment may be necessary to prevent relapse. |
| Databáze: | OpenAIRE |
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