Metabolic behavior and prognostic value of early and end of treatment 18F-FDG PET/CT in adult Burkitt’s lymphoma: the role of Deauville and IHP criteria
| Autor: | Raffaele Giubbini, Domenico Albano, Alessandro Re, Francesco Bertagna, Giovanni Bosio, Chiara Pagani |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cancer Research Burkitt’s lymphoma Adolescent PET/CT medicine.medical_treatment Kaplan-Meier Estimate Young Adult 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Adult Burkitt's lymphoma Positron Emission Tomography Computed Tomography Antineoplastic Combined Chemotherapy Protocols medicine Deauville criteria Humans Aged Retrospective Studies Aged 80 and over Chemotherapy PET-CT business.industry Disease Management International Harmonization Project Hematology Middle Aged Prognosis medicine.disease Burkitt Lymphoma Predictive value Interim pet Lymphoma Treatment Outcome Oncology 030220 oncology & carcinogenesis Female Fdg pet ct Energy Metabolism business Nuclear medicine Burkitt's lymphoma Biomarkers 030215 immunology |
| Zdroj: | Leukemia & Lymphoma. 60:326-333 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.1080/10428194.2018.1482541 |
| Popis: | Burkitt's lymphoma is a lymphoma with unclear metabolic behavior at 18F-FDG-PET/CT and no validated criteria in treatment evaluation and prediction of outcome exist. Sixty-five patients were retrospectively included: all underwent baseline 18F-FDG-PET/CT, 56 interim PET/CT (iPET/CT) and 54 end of treatment PET/CT (eotPET/CT) after chemotherapy. Interim and eotPET/CT results were visually interpreted according to the criteria of the IHP and Deauville-five-point-scale. Results were correlated with PFS and OS to assess and to compare the predictive value of iPET and eotPET according to each criterion. All baseline PET/CT showed increased 18F-FDG uptake in nodal and extranodal lesions. The median PFS and OS were 44.6 and 48.2 months with 3-year and 5-year PFS of 76% and 62% and 3-year and 5-year OS of 71% and 57%, respectively. EotPET/CT results using DC and IHP significantly correlate with OS and PFS; while iPET/CT did not correlated with OS and PFS. |
| Databáze: | OpenAIRE |
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