Relation of ultrasonic backscatter and acoustic propagation properties to myofibrillar length and myocardial thickness
| Autor: | David C. Warltier, Theodore L. Rhyne, Patrick D. O’Brien, William D. O'Brien, Kiran B. Sagar |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Sarcomeres Microscope Backscatter Systole Diastole Sarcomere law.invention Dogs law Physiology (medical) Medicine Animals Ultrasonics Microscopy business.industry Ultrasound Heart Anatomy Attenuation coefficient Ultrasonic sensor Female Cardiology and Cardiovascular Medicine business Biomedical engineering |
| Zdroj: | Circulation. 91(1) |
| ISSN: | 0009-7322 |
| Popis: | Background Ultrasonic backscatter demonstrates a cardiac cycle–dependent modulation. The exact mechanism of the modulation is under debate. The objective of the present study was to test the hypothesis that a change in size and configuration of myofilaments from systole to diastole alters acoustic propagation properties and backscatter. Methods and Results In vivo measurements were made of integrated backscatter at 5 MHz (IBR5), followed by in vitro measurements of ultrasonic attenuation, speed, and heterogeneity index using a scanning laser acoustic microscope at 100 MHz. Studies were performed in canine hearts (16) arrested in systole (8) with calcium chloride or arrested in diastole (8) with potassium chloride. Sarcomere length was measured with a calibrated eyepiece on a Ziess microscope. Wall thickness was measured with calipers. The attenuation coefficient of 220±34 dB/cm during systole was significantly higher than the coefficient of 189±24 dB/cm during diastole ( P P P P P P Conclusions Ultrasonic backscatter and propagation properties are directly related to sarcomere length and myocardial thickness and may be responsible for cardiac cycle–dependent variation in backscatter. |
| Databáze: | OpenAIRE |
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