Development of a multi-residue method for the determination of 18 carbamates in tobacco by high-performance liquid chromatography/positive electrospray ionisation tandem mass spectrometry
| Autor: | B. Mayer-Helm, J. Müller, L. Hofbauer |
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| Rok vydání: | 2006 |
| Předmět: |
Residue (complex analysis)
Electrospray Spectrometry Mass Electrospray Ionization Chromatography Organic Chemistry Selected reaction monitoring Pesticide Residues Reference Standards Tandem mass spectrometry High-performance liquid chromatography Sensitivity and Specificity Analytical Chemistry Dilution chemistry.chemical_compound chemistry Tobacco Sample preparation Carbamates Ammonium acetate Spectroscopy Chromatography High Pressure Liquid |
| Zdroj: | Rapid communications in mass spectrometry : RCM. 20(4) |
| ISSN: | 0951-4198 |
| Popis: | A multi-residue method for the determination of carbamates in tobacco was developed by high-performance liquid chromatography (HPLC) triple quadrupole mass spectrometry (MS). A rapid sample preparation consisted of an extraction step with methanol, centrifugation and 1:1 dilution with aqueous 10 mM ammonium acetate. After filtration these extracts were directly analysed by reversed-phase HPLC coupled to positive electrospray ionisation tandem mass spectrometry operated in the multiple reaction monitoring mode. Capillary voltage and dwell times were optimised to reduce matrix effects and to increase sensitivity. The method was validated for the determination of 18 carbamates in three main types of raw tobacco and three tobacco products. The interday accuracy ranged between 80 and 110% with a relative standard deviation (RSD) of |
| Databáze: | OpenAIRE |
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