Tissue Factor-Targeted 'O2-Evolving' Nanoparticles for Photodynamic Therapy in Malignant Lymphoma
| Autor: | Ziying Li, Yanxue Yin, Weiwei Jin, Bo Zhang, Han Yan, Heng Mei, Huafang Wang, Tao Guo, Wei Shi, Yu Hu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research EGFP-EGF1protein medicine.medical_treatment Photodynamic therapy macromolecular substances lcsh:RC254-282 03 medical and health sciences Tissue factor 0302 clinical medicine In vivo hemic and lymphatic diseases medicine biology medicine.diagnostic_test business.industry catalase Therapeutic effect tissue factor lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease In vitro Lymphoma 030104 developmental biology photodynamic therapy Oncology Catalase Positron emission tomography 030220 oncology & carcinogenesis biology.protein Cancer research nanoparticles business |
| Zdroj: | Frontiers in Oncology, Vol 10 (2020) |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2020.524712 |
| Popis: | Vascular-targeted PDT (vPDT) has produced promising results in the treatment of many cancers, including drug-resistant ones, but little is known about its efficacy in lymphoma. Unfortunately, the lack of a specific therapeutic target and a hypoxic microenvironment for lymphoma jeopardizes the efficacy of vPDT severely. In this study, we designed a lymphoma tissue factor-targeted “O2-evolving” strategy combining PDT with catalase and HMME-encapsulated, EGFP-EGF1-modified PEG-PLGA nanoparticles (CENPs) to boost PDT efficiency; this combination takes advantage of the low oxygen tension of lymphoma. In our results, CENPs accumulated effectively in the vascular lymphoma in vivo and in vitro, and this accumulation increased further with PDT treatment. Per positron emission tomography imaging, combining CENPs with PDT inhibited lymphoma glucose metabolism significantly. The expression of hypoxia-inducible factor (HIF)-1α in the entrapped catalase groups reduced markedly. These data show that the combined administration of PDT and CENPs can prompt tissue factor-cascade-targeted and self-supply of oxygen and that it has a good therapeutic effect on malignant lymphoma. |
| Databáze: | OpenAIRE |
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