Evaluation of alveolo-capillary permeability in thyrotoxicosis using Tc-99m DTPA aerosol scintigraphy
| Autor: | Selva Mert, Aziz Gültekin, Mahmut Yüksel, Şakir Berkarda |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Membrane permeability Vascular permeability Scintigraphy Pulmonary function testing Capillary Permeability Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Radionuclide Imaging Aged Aerosols Lung medicine.diagnostic_test business.industry Thyroid General Medicine Middle Aged Pulmonary Alveoli Thyrotoxicosis Endocrinology medicine.anatomical_structure Breathing Technetium Tc 99m Pentetate Female Radiopharmaceuticals business Half time |
| Zdroj: | Annals of Nuclear Medicine. 19:193-196 |
| ISSN: | 1864-6433 0914-7187 |
| Popis: | Surfactant secreted from type II pneumocytes plays an important role in alveolo-capillary permeability. In thyrotoxicosis, high levels of T3 receptors detected at these cells might affect the alveolo-capillary permeability due to increased serum thyroid hormone levels. The results by CO-diffusion capacity measurement in thyrotoxicosis are conflicting. Changes in alveolo-capillary membrane permeability resulting from thyrotoxicosis are not well established yet. This prompted us to investigate the alveolo-capillary permeability in thyrotoxic patients in comparison with CO-diffusing capacity. For this aim twenty-two non-smoking thyrotoxic patients (before treatment) and fifteen healthy voluntary controls underwent 99mTc-DTPA aerosol scintigraphy. CO-diffusing and pulmonary function tests were performed in all subjects. After ventilation of radiotracer through a nebulizer for 15 minutes, 30 dynamic images (1 frame/minute) were taken from both lungs. ROI's were drawn over both lung areas, and the time-activity curves were generated. Then clearance half time (CT1/2) for radioaerosol was obtained. CT1/2 of thyrotoxic patients did not differ from that of the controls: 77.9 +/- 25.9 min vs. 79.4 +/- 22.3 min; p0.05. Similar result was found for CO-diffusion parameters. Also there was no significant correlation between CT1/2 and CO-diffusion parameters. We concluded that in patients with thyrotoxicosis, the alveolo-capillary permeability is unaffected. Further experimental research is needed to establish the possible effects of thyroid hormones on alveolo-capillary membrane. |
| Databáze: | OpenAIRE |
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