The mammary factor MPBF is a prolactin-induced transcriptional regulator which binds to STAT factor recognition sites

Autor: Thomas G. Burdon, Christine J. Watson, A. John Clark, Jerome Demmer
Rok vydání: 1994
Předmět:
Lactoglobulins
Signal transduction
Biochemistry
Mice
0302 clinical medicine
Structural Biology
Interferon
Transcriptional regulation
Mammary Glands
Animal/physiology
STAT1
STAT2
Cells
Cultured
0303 health sciences
DNA-Binding Proteins/metabolism
biology
STAT
DNA-Binding Proteins
Phosphoproteins/metabolism
Oligodeoxyribonucleotides
030220 oncology & carcinogenesis
Tyrosine/metabolism
medicine.drug
Oligodeoxyribonucleotides/chemistry
Prolactin/pharmacology
Mammary gland
Molecular Sequence Data
Biophysics
In Vitro Techniques
stat
03 medical and health sciences
Mammary Glands
Animal
Consensus Sequence
Genetics
medicine
Animals
Humans
Transcription Factors/metabolism
Tyrosine/analogs & derivatives
Binding site
Phosphotyrosine
Molecular Biology
Transcription factor
030304 developmental biology
Binding Sites
Base Sequence
Activator (genetics)
Cell Biology
Phosphoproteins
Molecular biology
Prolactin
Molecular Weight
Lactoglobulins/genetics
biology.protein
Tyrosine
Transcription Factors
Zdroj: Burdon, T, Demmer, J, Clark, A J & Watson, C J 1994, ' The mammary factor MPBF is a prolactin-induced transcriptional regulator which binds to STAT factor recognition sites ', FEBS Letters, vol. 350, no. 2-3, pp. 177-82 .
ISSN: 0014-5793
DOI: 10.1016/0014-5793(94)00757-8
Popis: Site-directed mutagenesis of the three binding sites for the mammary factor MPBF in the β-lactoglobulin (BLG) promoter demonstrates that MPBF is a transcriptional activator of the BLG gene in mammary cells. MPBF requires phosphorylation on tyrosine for maximum binding activity and binds to GAS (interferon γ-activation site) elements which are similar to the MPBF binding sites. Prolactin induces MPBF binding activity in CHO cells and is not antigenically related to Stat1 (p91) and Stat2 (p113), suggesting that this transcription factor is likely to be another member of the STAT family of cytokine/growth factor-induced transcription factors.
Databáze: OpenAIRE
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