Cellular and molecular mechanisms of genistein in prevention and treatment of diseases: An overview
| Autor: | Fereshteh Nazari-Khanamiri, Morteza Ghasemnejad-Berenji |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
medicine.drug_class medicine.medical_treatment Biophysics Genistein Phytoestrogens Pharmacology Antioxidants Anti-inflammatory chemistry.chemical_compound medicine SOY ISOFLAVONES business.industry food and beverages Cancer Cell Biology Isoflavones medicine.disease chemistry Hormone receptor Postmenopausal symptoms Soybeans business Food Science |
| Zdroj: | Journal of Food Biochemistry. 45 |
| ISSN: | 1745-4514 0145-8884 |
| Popis: | Genistein is the simplest secondary metabolite in soybeans and belongs to a group of compounds called isoflavones. It is a phytoestrogen and it makes up more than 60% of soy isoflavones. Studies have shown the anti-inflammatory, anti-apoptotic, and anti-angiogenic effects of genistein in addition to its modulatory effects on steroidal hormone receptors. In this review, we discuss the pharmacologic and therapeutic effects of genistein on various diseases. PRACTICAL APPLICATIONS: In this review, we have discussed the therapeutic effects of genistein as the main constituent of soybeans on health conditions. Its antioxidant, anti-inflammatory, anti-apoptotic and, anti-angiogenic effects need more attention. The pharmacological properties of genistein make this natural isoflavone a potential treatment for various diseases such as postmenopausal symptoms, cancer, bone, brain, and heart diseases. Special emphasis should be given to it, resulting in using it in clinical as a safe, potent, and bioactive molecule. |
| Databáze: | OpenAIRE |
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