The effect of MK-801 and SCH23390 on the expression and sensitization of morphine-induced oral stereotypy
| Autor: | Conan Kornetsky, Livezey Rt, Pearce Lb |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Narcotics medicine.drug_class Pharmacology Receptors N-Methyl-D-Aspartate Rats Sprague-Dawley Dopamine Animals Medicine Receptor Molecular Biology Sensitization Mouth Morphine business.industry Receptors Dopamine D1 General Neuroscience Glutamate receptor Benzazepines Receptor antagonist Rats Stereotypy (non-human) medicine.anatomical_structure Dopamine Antagonists NMDA receptor Neurology (clinical) Dizocilpine Maleate Stereotyped Behavior business Excitatory Amino Acid Antagonists Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 692:93-98 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(95)00627-3 |
| Popis: | Repeated high doses of morphine sulfate, administered in a 24–36 h period, stimulates the expression of oral stereotypy in rats. Sensitization to this effect of morphine is demonstrated by the reexpression of the stereotypy by the administration of 4.0 mg/kg of morphine one week following the original exposure. To investigate the role of N -methyl- d -aspartic acid (NMDA) and D 1 dopamine (DA) receptors in the acute expression and sensitization of morphine-induced oral stereotypy, rats were administered four injections of morphine (10.0 mg/kg) one injection every 12 h and observed for the expression of stereotyic behaviors following pretreatment with selective antagonists. Pretreatment with the NMDA antagonist, MK-801 (0.7 mg/kg), before each of the four morphine injections antagonized both the initial expression of oral stereotypy and the development of sensitization. In contrast, the DA D 1 receptor antagonist SCH23390 (40.0 μg/kg) administered during the four high-dose treatments with morphine antagonized the initial expression of oral stereotypy and not the development of sensitization. These findings implicate glutamate's action at the NMDA receptor in both the acute expression of morphine-induced oral stereotypy, and the development of sensitization of this morphine effect, whereas DA D 1 receptors may only be involved in the acute expression of the stereotypy. |
| Databáze: | OpenAIRE |
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