Ameliorative activity of Adansonia digitata fruit on high sugar/high fat diet-simulated Metabolic Syndrome model in male Wistar rats
| Autor: | Iman H. Abdoon, A.M. Saad, Bashier Osman, Hassan S. Khalid, Hayat Mohamed Suliman |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine medicine.medical_specialty Dietary Sugars RM1-950 Diet High-Fat medicine.disease_cause Antioxidants 03 medical and health sciences chemistry.chemical_compound Adansonia 0302 clinical medicine Weight loss Internal medicine medicine Animals Rats Wistar Metabolic Syndrome Pharmacology Kidney Creatinine business.industry General Medicine medicine.disease Animal Feed Rats 030104 developmental biology medicine.anatomical_structure Endocrinology Liver chemistry Oxidative stress Simvastatin Fruit 030220 oncology & carcinogenesis High sugar/high fat diet Therapeutics. Pharmacology Adansonia digitata fruit medicine.symptom Metabolic syndrome business Weight gain Biomarkers Dyslipidemia medicine.drug |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 125, Iss, Pp 109968-(2020) |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2020.109968 |
| Popis: | Metabolic syndrome is a complex of metabolic disorders characterized by oxidative stress which compromises cell functions and entails multiple organs pathologies. We investigated the therapeutic and protective potential of Adansonia digitata fruit –a potent antioxidant– in high sugar/high fat diet-simulated metabolic syndrome in Wistar rats. 42 male rats (140–200 g) were randomly divided into 7 groups. G1 was kept on standard laboratory diet (SLD) for all 9 weeks (negative control). 5 groups were fed high Sugar/high fat diet for 6 weeks then switched to SLD for another 3 weeks + oral treatment as follows: G2+ no treatment (positive control), G3-G5 + 200, 400 and 800 mg/kg/day aqueous A. digitata fruit respectively, G6 + 10 mg/kg/day Simvastatin. G7 + HS/HFD + 400 mg/kg/day A. digitata fruit simultaneously and was terminated at W6. Our results showed that G2-G6 develops dyslipidemia, hyperglycaemia, weight gain, elevated hepatic biomarkers, elevated creatinine and urea plus pathological derangements in the heart, liver and kidney tissues compared to negative control at W6. 200 mg/kg/day A. digitata fruit significantly ameliorated the induced dyslipidemia (P ≤ 0.001), hyperglycaemia (P ≤ 0.001) with a significant reduction in the Atherogenic Index of Plasma (P ≤ 0.000) after 3 weeks treatment. The fruit normalized the elevated hepatic biomarkers as well as creatinine and urea. A dose dependent partial reduction in lesion intensity was observed in the hepatic tissue while the heart and kidney showed mostly reversed to normal histology. The inflammatory infiltration was eliminated. Relevant results were observed for the two higher doses. The simultaneous treatment showed significant lower levels in all biomarkers investigated compared to positive control which could be interpreted as protective activity. A reduction of 4–11% in whole body weight was achieved. Conclusion MetS was successfully simulated with a HS/HFD formula in male Wistar rats. Treatment with aqueous A. digitata fruit showed anti-Metabolic Syndrome potential reflected by weight loss, anti-inflammatory, hypolipidemic, hypoglycaemic, renal, hepatic and cardio-protective activities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect