Outcomes of newly diagnosed myeloma patients requiring dialysis: renal recovery, importance of rapid response and survival benefit
| Autor: | Despoina Mparmparoussi, Dimitrios C. Ziogas, Meletios A. Dimopoulos, Evangelos Eleutherakis-Papaiakovou, Maria Gavriatopoulou, E. Terpos, Dimitra Bacharaki, Ioannis Panagiotidis, Stavroula Giannouli, Magdalini Migkou, Charis Matsouka, Smaragdi Marinaki, Maria Roussou, E Kastritis, Erasmia Psimenou, N. Kanellias, Despina Fotiou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Context (language use) Single Center Kidney Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Renal Dialysis Internal medicine medicine Humans Intensive care medicine Survival rate Letter to the Editor Dialysis Aged Aged 80 and over business.industry Acute kidney injury Hematology Recovery of Function Middle Aged medicine.disease 3. Good health Discontinuation Clinical trial Survival Rate Oncology 030220 oncology & carcinogenesis Female Hemodialysis business Multiple Myeloma 030215 immunology |
| Zdroj: | Blood Cancer Journal |
| ISSN: | 2044-5385 |
| Popis: | About 50% of newly diagnosed mutilple myeloma (MM) patients (NDMM) have some degree of renal impairment (RI) at presentation, up to 20% have severe acute kidney injury (AKI) and ~1–5% may require extrarenal dialysis, whereas severe RI is associated with high risk of early death and other complications.1, 2 Immediate effective anti-myeloma therapy and vigorous supportive care are the cornerstones of management.2, 3 However, there are limited data focusing specifically on the management and outcomes of MM patients requiring dialysis as a consequence of MM, mostly including small numbers of patients on dialysis.4, 5, 6, 7, 8 Moreover, the use of high cut-off hemodialysis to rapidly reduce the load of nephrotoxic light chains may provide some additional benefit in patients requiring dialysis when treated with bortezomib-based therapies, but the reported results of two randomized studies are controversial.9, 10 Thus, we analyzed the outcomes of 52 consecutive NDMM with RI requiring dialysis, which were managed and treated in a single center, to provide data on response to therapy, dialysis discontinuation and survival in unselected patients, outside the context of clinical trials. |
| Databáze: | OpenAIRE |
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