Sibling oocyte submission to IVF and ICSI in unexplained infertility patients: a potential assay for gamete quality
| Autor: | Benjamin Reubinoff, Hagar Gino, Alex Simon, Neri Laufer, Anat Safran, David Shveiky, Aby Lewin, Ariel Revel |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_treatment Fertilization in Vitro Intracytoplasmic sperm injection Andrology Human fertilization medicine Humans Sperm Injections Intracytoplasmic Sibling reproductive and urinary physiology Unexplained infertility Pregnancy urogenital system business.industry Siblings Obstetrics and Gynecology Oocyte medicine.disease Spermatozoa Embryo transfer medicine.anatomical_structure Reproductive Medicine Infertility embryonic structures Oocytes Gamete business therapeutics Developmental Biology |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1472-6483 |
| DOI: | 10.1016/s1472-6483(10)61011-5 |
| Popis: | In order to reduce total fertilization failure in unexplained infertility, sibling oocytes were submitted to both conventional IVF and intracytoplasmic sperm injection (ICSI). Two groups of ICSI embryos were compared in unexplained infertility patients: those derived from ICSI when IVF had failed to fertilize, and those derived from ICSI while their sibling oocytes were fertilized by IVF. The outcome of oocytes fertilized exclusively by ICSI (essential ICSI, n = 749) was compared with those fertilized both by IVF and ICSI (non-essential ICSI, n = 957) in all IVF patients treated for unexplained infertility at the Hadassah Hospital (1999–2002). The latter group was further subdivided into ICSI and IVF embryos. Total fertilization rate was 54%. Fertilization rates by ICSI were lower in the essential ICSI compared with the non-essential ICSI group, at 65 and 73% (P < 0.025). Pregnancy rates per embryo transfer in the essential ICSI group (49%), ICSI derived embryos group (55%) and IVF derived embryos (44%) from the non-essential ICSI group, were similar. Implantation rates were lower in the essential ICSI group as compared with the non-essential ICSI group (21 versus 32% respectively; P < 0.05) and 26% for IVF embryos. In conclusion, essential ICSI was associated with lower fertilization and implantation rates. |
| Databáze: | OpenAIRE |
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