Gene activation therapy from the BLV model to HAM TSP patients
| Autor: | Becca Asquith, Raymond Césaire, Amel Bouzar, Charles R. M. Bangham, Arsène Burny, Arnaud-Francois Florins, Stéphane Olindo, Luc Willems, Aissatou Signate, Julien Defoiche, Derek C. Macallan, Agnès Lézin, Gildas Belrose, Didier Smadja, Olivier Verlaeten, Nicolas Gillet |
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| Rok vydání: | 2009 |
| Předmět: |
Regulation of gene expression
Sheep General Immunology and Microbiology Bovine leukemia virus biology viruses Gene Expression Genetic Therapy Provirus biology.organism_classification medicine.disease Models Biological Virology Paraparesis Tropical Spastic General Biochemistry Genetics and Molecular Biology Virus Immune system Immunology Gene expression Tropical spastic paraparesis Leukemia Virus Bovine medicine Animals Humans Epigenetics |
| Zdroj: | Frontiers in Bioscience. :205-215 |
| ISSN: | 1945-0524 1945-0516 |
| DOI: | 10.2741/s20 |
| Popis: | HTLV-1 (human T-lymphotropic virus type 1) and BLV (bovine leukemia virus) are two related retroviruses infecting CD4+ and B lymphocytes in humans and ruminants, respectively. During infection, the host-pathogen interplay is characterized by very dynamic kinetics resulting in equilibrium between the virus, which attempts to proliferate, and the immune response, which seeks to exert tight control of the virus. A major determinant of disease induction by both viruses is the accumulation of provirus in peripheral blood. In the absence of viral proteins, virus infected cells escape recognition and destruction by the host immune response. We propose a novel therapeutic strategy based on transient activation of viral expression using epigenetic modulators; this exposes infected cells to the immune response and results in significant reductions in proviral loads. In the absence of satisfactory therapies, this viral gene-activation strategy might delay progression, or even be curative, for HTLV-1 induced myelopathy / tropical spastic paraparesis (HAM/TSP). |
| Databáze: | OpenAIRE |
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