The effects of long-term diet and omega-3 fatty acid supplementation on coagulation factor VII and serum phospholipids with special emphasis on the R353Q polymorphism of the FVII gene
| Autor: | Anja Schou Lindman, Harald Arnesen, Jan I. Pedersen, Ingrid Ellingsen, Ingebjørg Seljeflot, Marit B. Veierød, Elsa M. Hjerkinn |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Risk medicine.medical_specialty Arteriosclerosis Mutation Missense Phospholipid Coronary Disease Placebo Polymorphism Single Nucleotide law.invention chemistry.chemical_compound Randomized controlled trial law Internal medicine Fatty Acids Omega-3 Genotype Humans Medicine Phospholipids Triglycerides Coagulation factor VII Aged Factor VII business.industry Hematology Surgery Endocrinology chemistry Dietary Supplements Phosphatidylcholines Omega 3 fatty acid supplementation business Corn oil |
| Zdroj: | Thrombosis and Haemostasis. 91:1097-1104 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1160/th03-12-0773 |
| Popis: | SummaryThe aim of the present study was to investigate the effect of long-term diet and very long chain n-3 fatty acids (VLC n-3) intervention on plasma coagulation factor VII (FVII), cholinecontaining phospholipids (PC) and triglycerides (TG), especially related to the R353Q polymorphism of the FVII gene. The present investigation included 219 subjects from the Diet and Omega-3 Intervention Trial on atherosclerosis (DOIT), a 2x2 factorial designed study in elderly men with long-standing hypercholesterolemia. The subjects were randomly allocated to receive placebo capsules (corn oil) (control), placebo capsules and dietary advice (“Mediterranean type” diet), VLC n-3 capsules, or VLC n-3 capsules and dietary advice combined. The R353Q genotype and the levels of FVIIc, FVIIag, FVIIa, PC, and TG at baseline and after 6 months were determined. Diet interention was followed by a significant reduction of 5.1% in the levels of FVIIag and 2.4 mU/ml in FVIIa (95% CI −7.4, −2.9, and −3.8, −1.1, respectively) (both p |
| Databáze: | OpenAIRE |
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