The effects of propofol on neutrophil function, lipid peroxidation and inflammatory response during elective coronary artery bypass grafting in patients with impaired ventricular function
| Autor: | S. O'Callaghan-Enright, A. O'Shea, Tomas Corcoran, H. Sakamoto, George D. Shorten, A. Engel |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Isoprostane Neutrophils Myocardial Reperfusion Injury law.invention Ventricular Dysfunction Left Coronary artery bypass surgery chemistry.chemical_compound Reperfusion therapy law Malondialdehyde medicine.artery Internal medicine medicine Cardiopulmonary bypass Humans Coronary Artery Bypass Propofol Coronary sinus Aged Respiratory Burst Aorta business.industry Interleukins Middle Aged medicine.disease Anesthesiology and Pain Medicine chemistry Anesthesia Cardiology Female Lipid Peroxidation Inflammation Mediators business Reperfusion injury Anesthetics Intravenous medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 97:825-831 |
| ISSN: | 0007-0912 |
| DOI: | 10.1093/bja/ael270 |
| Popis: | Coronary artery bypass grafting (CABG) with cardiopulmonary bypass elicits a potent reperfusion injury and inflammatory response, more intense in patients with impaired myocardial function. Propofol has antioxidant properties which may attenuate such a response.In total, 27 patients with impaired left ventricular function undergoing CABG were randomly allocated to receive either target-controlled infusion propofol (P) or saline (S) immediately before aortic cross-clamp release until 4 h after reperfusion. Troponin-I, Urinary 8-epi PGF-2alpha isoprostane, coronary sinus and systemic malondialdehyde concentrations, Interleukin-6 (IL-6), -8 and -10 concentrations and leucocytes function studies (neutrophil respiratory burst, phagocytosis, CD-11b and CD-18 expression) were measured.Propofol decreased MDA coronary sinus concentration at 1, 3 and 5 min after reperfusion (P0.01); 60 min after reperfusion a significant difference between the two groups in systemic MDA concentrations was also seen. IL-6 concentration increases were significantly greater in Group S than Group P, 4 h after reperfusion [1118 (1333) pg ml(-1) vs 228 (105) pg ml(-1), P0.01]. Serum IL-8 concentrations did not increase significantly in either group. Compared with baseline values IL-10 concentrations decreased after reperfusion but the values were higher in the propofol group than in the control group [22 (16) vs 11 (4) pg ml(-1), P0.05]. No difference in leucocyte function or urinary isoprostane concentrations was demonstrated.Propofol attenuates free-radical-mediated lipid peroxidation and systemic inflammation in patients with impaired myocardial function undergoing CABG. |
| Databáze: | OpenAIRE |
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