Pristane-induced effects on cytochrome P-4501A, ornithine decarboxylase and putrescine in rats
| Autor: | Madhusudan G. Soni, Harihara M. Mehendale, Marvin A. Cuchens, Carolyn M. Harper |
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| Rok vydání: | 1995 |
| Předmět: |
Cancer Research
medicine.medical_specialty Carboxy-lyases Ornithine Decarboxylase Ornithine decarboxylase chemistry.chemical_compound Cytochrome P-450 Enzyme System Microsomes Internal medicine Cytochrome P-450 CYP1A1 Putrescine medicine Animals Tissue Distribution biology Terpenes Pristane Cytochrome P450 Rats Endocrinology Oncology chemistry Biochemistry Enzyme Induction Toxicity Microsome biology.protein Female Oxidoreductases Polyamine Methylcholanthrene |
| Zdroj: | Cancer Letters. 95:11-21 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/0304-3835(95)03855-q |
| Popis: | The effects of pristane (2,6,10,14-tetramethylpentadecane) on cytochrome P-4501A(cP4501A) activity in microsomes, as well as on ornithine decarboxylase (ODC) activity and concomitant putrescine levels were examined in Copenhagen rats. In general, pristane treatment led to increased cP4501A levels when compared to basal levels, while co-treatment with 3-methylcholanthrene (3-MC) and pristane elicited augmented cP4501 A responses when compared to responses induced by 3-MC alone. Increases in both ODC activity and putrescine levels were also observed in pristane treated rats. Collectively, these results indicate that pristane influences cP4501A activity and elicits promoter-like responses as reflected in elevated ODC activity and increased amount of putrescine. |
| Databáze: | OpenAIRE |
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