Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion
| Autor: | Rajesh N. Kukunoor, Jeffrey Warren Allen, Agnes K. Liman, Glen J. Weiss, Philip Y. Cheung |
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| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty Squamous-cell carcinoma of the lung Lung biology business.industry lcsh:R lcsh:Medicine Case Report General Medicine medicine.disease Metastasis Exon medicine.anatomical_structure Symptom relief Mutation testing Cancer research medicine biology.protein Epidermal growth factor receptor business Egfr tyrosine kinase |
| Zdroj: | Case Reports in Medicine, Vol 2013 (2013) Case Reports in Medicine |
| ISSN: | 1687-9635 1687-9627 |
| DOI: | 10.1155/2013/874836 |
| Popis: | We describe three confirmed cases of squamous cell carcinoma (SCC) of the lung with metastasis to the gastrointestinal (GI) tract, with two having epidermal growth factor receptor (EGFR) exon 19 deletions in all available specimens. One of these patients received EGFR tyrosine kinase directed therapy for a brief period with some symptom relief. Consideration of EGFR exon 19 mutation testing in SCC of the lung, particularly for those with GI tract metastasis, may identify this potentially drug-targetable entity. |
| Databáze: | OpenAIRE |
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