Biological roles of Yin Yang 2: Its implications in physiological and pathological events
Autor: | Yanjun Li, Ian Timothy Sembiring Meliala, Vivi Kasim, Lang Li, Shourong Wu |
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Rok vydání: | 2020 |
Předmět: |
Transcriptional Activation
0301 basic medicine Reviews Repressor Cellular homeostasis Review Biology YY2 immune response Mice 03 medical and health sciences 0302 clinical medicine Immune system Neoplasms Gene expression Animals Homeostasis Humans cancer development YY family Gene Embryonic Stem Cells YY1 Transcription Factor Cell Proliferation Zinc finger Binding Sites YY1 Stem Cells Cell Differentiation Cell Biology Prognosis Embryonic stem cell humanities Cell biology 030104 developmental biology Immune System 030220 oncology & carcinogenesis Molecular Medicine Protein Processing Post-Translational Transcription Factors |
Zdroj: | Journal of Cellular and Molecular Medicine |
ISSN: | 1582-4934 1582-1838 |
Popis: | Yin yang 2 (YY2) is a multifunctional zinc finger protein that belongs to the yin yang (YY) family. YY2 has dual function in regulating gene expression, as it could act either as a transcriptional activator or as a repressor of its target genes. YY2 could regulate genes that have been previously identified as targets of yin yang 1 (YY1), another member of the YY family, by binding to their common binding sequences. However, recent studies revealed that YY2 also has its own specific binding sequences, leading to its particular biological functions distinct from those of YY1. Furthermore, they have different levels or even opposite regulatory effects on common target genes, suggesting the importance of balanced YY1 and YY2 regulations in maintaining proper cellular homeostasis and biological functions. Recent studies revealed that YY2 plays crucial roles in maintaining stemness and regulating differentiation potential of embryonic stem cells, as well as in the development of the brain, nervous and cardiovascular systems. YY2 expression is also closely related to diseases, as it could act as a tumour suppressor gene that regulates tumour cell proliferation and metastasis. Moreover, YY2 is also involved in immune regulation and immune surveillance. Herein, we summarize recent perspectives regarding the regulatory functions of YY2, as well as its biological functions and relation with diseases. |
Databáze: | OpenAIRE |
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