Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength
| Autor: | Anton J. M. de Craen, Diana van Heemst, P.E. Slagboom, Karel G M Beenakker, Rudi G. J. Westendorp, Andrea B. Maier |
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| Přispěvatelé: | Internal medicine, MOVE Research Institute, Neuromechanics, AMS - Ageing and Morbidity |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Lipopolysaccharides
Muscle tissue Male Aging medicine.medical_specialty Lipopolysaccharide Lipoproteins Skeletal/immunology Stimulation Inflammation Biology Lipoproteins/immunology Peripheral blood mononuclear cell Monocytes Body Mass Index Interferon-gamma chemistry.chemical_compound Sex Factors SDG 3 - Good Health and Well-being Monocytes/drug effects Internal medicine Toll-Like Receptor 4/agonists medicine Humans Lipopolysaccharides/immunology Longitudinal Studies Muscle Strength Muscle Skeletal Aged Interleukin-6 Monocyte Skeletal muscle Cell Biology Muscle Skeletal/immunology Middle Aged Toll-Like Receptor 4 medicine.anatomical_structure Endocrinology chemistry Interferon-gamma/immunology Lean body mass Muscle Female Interleukin-6/immunology medicine.symptom |
| Zdroj: | Aging Cell, 12(4), 682-689. Wiley-Blackwell Beenakker, K G M, Westendorp, R G J, de Craen, A J M, Slagboom, P E, van Heemst, D & Maier, A B 2013, ' Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength ', Aging Cell, vol. 12, no. 4, pp. 682-9 . https://doi.org/10.1111/acel.12095 Aging Cell, 12(4), 682-9. Wiley-Blackwell Beenakker, K G M, Westendorp, R G J, Craen, A J M, Slagboom, P E, van Heemst, D & Maier, A B 2013, ' Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength ', Aging Cell, vol. 12, no. 4, pp. 682-689 . https://doi.org/10.1111/acel.12095 Aging Cell, 12(4), 682-9 |
| ISSN: | 1474-9718 |
| DOI: | 10.1111/acel.12095 |
| Popis: | In mice, monocytes that exhibit a pro-inflammatory profile enter muscle tissue after muscle injury and are crucial for clearance of necrotic tissue and stimulation of muscle progenitor cell proliferation and differentiation. The aim of this study was to test if pro-inflammatory capacity of classically activated (M1) monocytes relates to muscle mass and strength in humans. This study included 191 male and 195 female subjects (mean age 64.2 years (SD 6.4) and 61.9 ± 6.4, respectively) of the Leiden Longevity Study. Pro-inflammatory capacity of M1 monocytes was assessed by ex vivo stimulation of whole blood with Toll-like receptor (TLR) 4 agonist lipopolysaccharide (LPS) and TLR-2/1 agonist tripalmitoyl-S-glycerylcysteine (Pam₃Cys-SK₄), both M1 phenotype activators. Cytokines that stimulate M1 monocyte response (IFN-γ and GM-CSF) as well as cytokines that are secreted by M1 monocytes (IL-6, TNF-α, IL-12, and IL-1β) were measured. Analyses were adjusted for age, height, and body fat mass. Upon stimulation with LPS, the cytokine production capacity of INF-γ, GM-CSF, and TNF-α was significantly positively associated with lean body mass, appendicular lean mass and handgrip strength in men, but not in women. Upon stimulation with Pam₃Cys-SK₄, IL-6; TNF-α; and Il-1β were significantly positively associated with lean body mass and appendicular lean in women, but not in men. Taken together, this study shows that higher pro-inflammatory capacity of M1 monocytes upon stimulation is associated with muscle characteristics and sex dependent. |
| Databáze: | OpenAIRE |
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