Randomized Controlled Trial of a Cognitive Intervention to Improve Memory in Heart Failure
| Autor: | David G. Clark, Heather Burney, Marita G. Titler, Susan J. Pressler, Susan G. Dorsey, Irmina Gradus-Pizlo, Bruno Giordani, Sujuan Gao, Kelly L. Wierenga, Kittie Reid Lake, Miyeon Jung, Dean G. Smith |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Comparative Effectiveness Research
medicine.medical_specialty Activities of daily living Clinical Trials and Supportive Activities Clinical Sciences Nursing Cardiorespiratory Medicine and Haematology Cardiovascular computerized cognitive training Article law.invention Quality of life (healthcare) Cognition Randomized controlled trial cognitive dysfunction Clinical Research law Behavioral and Social Science Activities of Daily Living Medicine Humans nurse-enhancement intervention Heart Failure Cognitive Intervention Recall business.industry Working memory Prevention Brain-Derived Neurotrophic Factor Rehabilitation Cognitive training Cardiovascular System & Hematology Physical therapy Quality of Life Cardiology and Cardiovascular Medicine business |
| Zdroj: | J Card Fail Journal of cardiac failure, vol 28, iss 4 |
| Popis: | Background The objective of this 3-arm randomized controlled trial was to evaluate efficacy of computerized cognitive training (CCT) to improve primary outcomes of delayed recall memory and serum brain-derived neurotrophic factor (BDNF) levels and secondary outcomes of working memory, instrumental activities of daily living (IADL), and health-related quality of life (HRQL) among patients with heart failure (HF). Methods and Results Patients (N = 256) were randomly assigned to 8 weeks of CCT using BrainHQ, computerized crossword puzzles active control intervention, and usual care. All patients received weekly nurse enhancement interventions. Data were collected at enrollment and baseline visits and at 10 weeks and 4 and 8 months. In mixed effects models, there were no statistically significant group or group by time differences in outcomes. There were statistically significant differences over time in all outcomes in all groups. Patients improved over time on measures of delayed recall memory, working memory, IADL, and HRQL and had decreased serum BDNF. Conclusions CCT did not improve outcomes compared with the active control intervention and usual care. Nurse enhancement interventions may have led to improved outcomes over time. Future studies are needed to test nurse enhancement interventions in combination with other cognitive interventions to improve memory in HF. LaySummary In 256 patients with heart failure, 8 weeks of computerized cognitive training, computerized crossword puzzles, or usual care were studied for effects on (1st) recall memory and serum brain-derived neurotrophic factor (BDNF) and (2nd) working memory, instrumental activities of daily living (IADL), and health-related quality of life (HRQL). Measurements were at baseline, 10 weeks, 4- and 8-months. Nurse enhancement interventions (e.g., support, assessment) were provided. Recall memory, working memory, IADL, and HRQL improved over time. There were no statistically significant differences among treatment groups over time. BDNF unexpectedly decreased. Nurse enhancement interventions may explain improved outcomes. Future studies are needed. |
| Databáze: | OpenAIRE |
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