Bioinspired drug delivery strategies for repurposing conventional antibiotics against intracellular infections
| Autor: | Santhni Subramaniam, Chelsea Thorn, Clive Prestidge, Nicky Thomas, Paul Joyce |
|---|---|
| Přispěvatelé: | Subramaniam, Santhni, Joyce, Paul, Thomas, Nicky, Prestidge, Clive A |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.drug_class
media_common.quotation_subject Antibiotics Biological particles Pharmaceutical Science Microbiology Drug Delivery Systems medicine Animals Humans biomimetics Internalization Repurposing bio-formulation Immune Evasion media_common biology nanoantibiotics Intracellular parasite Drug Repositioning antibacterial resistance Bacterial Infections biology.organism_classification Anti-Bacterial Agents Drug delivery Infectious diseases nanoparticles Bacteria Intracellular |
| Popis: | Bacteria have developed a wealth of strategies to avoid and resist the action of antibiotics, one of which involves pathogens invading and forming reservoirs within host cells. Due to the poor cell membrane permeability, stability and retention of conventional antibiotics, this renders current treatments largely ineffective, since achieving a therapeutically relevant antibiotic concentration at the site of intracellular infection is not possible. To overcome such challenges, current antibiotics are 'repurposed' via reformu-lation using micro-or nano-carrier systems that effectively encapsulate and deliver therapeutics across cellular membranes of infected cells. Bioinspired materials that imitate the uptake of biological particu-lates and release antibiotics in response to natural stimuli are recently explored to improve the targeting and specificity of this 'nanoantibiotic' approach. In this review, the mechanisms of internalization and survival of intracellular bacteria are elucidated, effectively accentuating the current treatment challenges for intracellular infections and the implications for repurposing conventional antibiotics. Key case studies of nanoantibiotics that have drawn inspiration from natural biological particles and cellular uptake path-ways to effectively eradicate intracellular pathogens are detailed, clearly highlighting the rational for har-nessing bioinspired drug delivery strategies. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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