the food contaminant deoxynivalenol provokes metabolic impairments resulting in non-alcoholic fatty liver (NAFL) in mice
| Autor: | Jean-Denis Troadec, Kevin Poirot, Michel Dallaporta, Stéphanie Gaigé, Coraline Airault, Anne Abysique, Rym Barbouche |
|---|---|
| Přispěvatelé: | Laboratoire de Neurosciences Cognitives [Marseille] (LNC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Physiology medicine.medical_treatment Adipose tissue Environmental impact Mice Non-alcoholic Fatty Liver Disease 2. Zero hunger Multidisciplinary Fatty Acids Fatty liver Gastroenterology Endoplasmic Reticulum Stress Immunohistochemistry 3. Good health Liver Toxicity Lipogenesis Cytokines Medicine Inflammation Mediators Oxidation-Reduction Glycogen medicine.medical_specialty Lipolysis Science [SDV.TOX.TVM]Life Sciences [q-bio]/Toxicology/Vegetal toxicology and mycotoxicology Food Contamination [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain Hypoglycemia Article 03 medical and health sciences Internal medicine medicine Animals 030102 biochemistry & molecular biology business.industry Insulin Lipid Metabolism medicine.disease Animal Feed Hormones Disease Models Animal Metabolism 030104 developmental biology Endocrinology Steatosis Energy Metabolism Trichothecenes business Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2020, 10, pp.12072. ⟨10.1038/s41598-020-68712-w⟩ Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020) Scientific Reports, 2020, 10, pp.12072. ⟨10.1038/s41598-020-68712-w⟩ |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-68712-w⟩ |
| Popis: | The ribotoxin deoxynivalenol (DON) is a trichothecene found on cereals responsible for mycotoxicosis in both humans and farm animals. DON toxicity is characterized by reduced food intake, diminished nutritional efficiency and immunologic effects. The present study was designed to further characterize the alterations in energy metabolism induced by DON intoxication. We demonstrated that acute DON intoxication triggered liver steatosis associated with an altered expression of genes related to lipids oxidation, lipogenesis and lipolysis. This steatosis was concomitant to anorexia, hypoglycemia and a paradoxical transient insulin release. DON treatment resulted also in stimulation of central autonomic network regulating sympathetic outflow and adrenaline and glucocorticoids secretion. Furthermore, an increased expression of genes linked to inflammation and reticulum endoplasmic stress was observed in the liver of DON-treated mice. Finally, we propose that lipids mobilization from adipose tissues (AT) induced by DON intoxication drives hepatic steatosis since (1) genes encoding lipolytic enzymes were up-regulated in AT and (2) plasma concentration of triglycerides (TGs) and non-esterified fatty acids were increased during DON intoxication. Altogether, these data demonstrate that DON induced hormonal and metabolic dysregulations associated with a spectrum of hepatic abnormalities, evocative of a non-alcoholic fatty liver disease. |
| Databáze: | OpenAIRE |
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