CpG oligodeoxynucleotides augment the murine immune response to the Yersinia pestis F1-V vaccine in bubonic and pneumonic models of plague
| Autor: | Sarah L. Norris, Anthony D. Bassett, Bradford S. Powell, Patricia L. Worsham, Randy L. Fast, Jeffrey J. Adamovicz, Arthur M. Krieg, Kei Amemiya, Jennifer L. Meyers, Taralyn E. Rogers |
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| Rok vydání: | 2009 |
| Předmět: |
Pore Forming Cytotoxic Proteins
Yersinia pestis Ratón CpG Oligodeoxynucleotide Biology Bubonic plague Mice Immune system Adjuvants Immunologic Bacterial Proteins medicine Animals Antigens Bacterial Mice Inbred BALB C Plague Plague Vaccine Vaccines Synthetic General Veterinary General Immunology and Microbiology Vaccination Public Health Environmental and Occupational Health Yersiniosis hemic and immune systems respiratory system medicine.disease biology.organism_classification Antibodies Bacterial Virology Toll-Like Receptor 2 Infectious Diseases Oligodeoxyribonucleotides Immunology Molecular Medicine Plague vaccine Female |
| Zdroj: | Vaccine. 27:2220-2229 |
| ISSN: | 0264-410X |
| Popis: | The current U.S. Department of Defense candidate plague vaccine is a fusion between two Yersinia pestis proteins: the F1 capsular protein, and the low calcium response (Lcr) V-protein. We hypothesized that an immunomodulator, such as CpG oligodeoxynucleotide (ODN)s, could augment the immune response to the plague F1-V vaccine in a mouse model for plague. CpG ODNs significantly augmented the antibody response and efficacy of a single dose of the plague vaccine in murine bubonic and pneumonic models of plague. In the latter study, we also found an overall significant augmentation the immune response to the individual subunits of the plague vaccine by CpG ODN 2006. In a long-term, prime-boost study, CpG ODN induced a significant early augmentation of the IgG response to the vaccine. The presence of CpG ODN induced a significant increase in the IgG2a subclass response to the vaccine up to 5 months after the boost. Our studies showed that CpG ODNs significantly augmented the IgG antibody response to the plague vaccine, which increased the probability of survival in murine models of plague ( P |
| Databáze: | OpenAIRE |
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