CYTOTOXIC ACTIVITY OF KAEMPFEROL GLYCOSIDES AGAINST HUMAN LEUKAEMIC CELL LINES IN VITRO
| Autor: | Marios Marselos, Costas Demetzos, Sofia Mitaku, Dimitrios Kokkinopoulos, Theodoros Tzavaras, Kostas Dimas |
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| Rok vydání: | 2000 |
| Předmět: |
Cell Survival
Biology chemistry.chemical_compound Phenols Tumor Cells Cultured Humans Cytotoxic T cell Benzopyrans Glycosides Kaempferols Flavonoids Pharmacology chemistry.chemical_classification Platanus orientalis DNA synthesis Glycoside DNA biology.organism_classification Antineoplastic Agents Phytogenic In vitro chemistry Biochemistry Cell culture Quercetin Kaempferol Thymidine |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1043-6618 |
| DOI: | 10.1006/phrs.1999.0562 |
| Popis: | Two kaempferol coumaroyl glycosides (i.e. platanoside and tiliroside) isolated from the methanolic extract of Platanus orientalis L. buds, were examined for their in vitro cytotoxic activity against a panel of human leukaemic cell lines. Platanoside (1) exhibited cytotoxic activity against most of the cell lines tested, while tiliroside (2) was active against two of the nine tested cell lines. Compound 1, was examined for its effect on the uptake of [(3)H]thymidine as a marker of DNA synthesis. Kaempferol was used as a control. 2000 Academic Press@p$hr Copyright 2000 Academic Press. Pharmacol Res |
| Databáze: | OpenAIRE |
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