The effects of salicylate on the concentrations of amino-acids in mouse tissues
| Autor: | M. J. H. Smith, P. D. Dawkins |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Intraperitoneal injection Pharmaceutical Science In Vitro Techniques Biology Kidney Mice chemistry.chemical_compound Valine Internal medicine medicine Animals Amino Acids Transaminases Brain Chemistry Pharmacology Alanine Autoanalysis Ornithine Salicylates Glutamine medicine.anatomical_structure Endocrinology Liver chemistry Glycine Leucine Injections Intraperitoneal |
| Zdroj: | Journal of Pharmacy and Pharmacology. 22:913-922 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.1970.tb08473.x |
| Popis: | The concentrations of amino-acids in chopped preparations of mouse liver incubated with 0 to 20 mM salicylate were measured. The changes, observed with salicylate concentrations of 10 mM and above, were increased concentrations of aspartate, glutamine, tyrosine and ornithine and decreased concentrations of glutamate and γ-aminobutyrate. The effects of the intraperitoneal injection of salicylate, in doses ranging from 75 to 600 mg/kg body weight, on the amino-acid concentrations in mouse blood, kidney, liver and brain were studied. With a dose of 600 mg/kg, the amino-acid concentrations were decreased in the blood (except glutamate and aspartate which increased) and in the kidney, were increased in the liver (except glutamine, glutamate, glycine and alanine which decreased) and were unchanged in the brain (except alanine, valine and leucine which decreased and γ-aminobutyrate which increased). These changes may result from a combination of an inhibitory effect of salicylate on the renal tubular transport of the amino-acids and intracellular actions of the drug on aminotransferase and other enzyme activities. |
| Databáze: | OpenAIRE |
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