Direct assessment of adherence and drug interactions in patients with hypertensive crisis-A cross-sectional study in the Emergency Department

Autor: Sabine Blaschke, Nadine Lach, Eirini Mavropoulou, Myra-Lynn Chavanon, Elena Lowin, Christoph Herrmann-Lingen, Michael Koziolek, Gerhard A. Müller, Henrik Hiller, Manuel Wallbach, Johanna Stock, Hartmud Neurath
Rok vydání: 2018
Předmět:
Male
Drug
medicine.medical_specialty
Cross-sectional study
Endocrinology
Diabetes and Metabolism
media_common.quotation_subject
Therapeutics
Urine
Urinalysis
030204 cardiovascular system & hematology
Gas Chromatography-Mass Spectrometry
Medication Adherence
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Glycyrrhiza
Internal Medicine
medicine
Humans
Ingestion
Drug Interactions
Hypertensive emergency
Prospective Studies
030212 general & internal medicine
Glucocorticoids
Antihypertensive Agents
Aged
media_common
Aged
80 and over
business.industry
Anti-Inflammatory Agents
Non-Steroidal
Blood Pressure Determination
Emergency department
Middle Aged
medicine.disease
Hypertensive crisis
Antidepressive Agents
3. Good health
Hospitalization
Cross-Sectional Studies
Food
Concomitant
Hypertension
Female
Emergency Service
Hospital
Cardiology and Cardiovascular Medicine
business
Zdroj: J Clin Hypertens (Greenwich)
ISSN: 1524-6175
DOI: 10.1111/jch.13448
Popis: Though drug adherence is supposed to be low in hypertensive crisis (HTN‐C), there are no data available from direct adherence assessments. The aim of the present study was to evaluate adherence to prescribed antihypertensives and potential interactions of concomitant drugs and foods with prescribed antihypertensives in patients with HTN‐C by a direct evaluation via biochemical urine analysis. In the present cross‐sectional study, 100 patients with HTN‐C, admitted to the emergency department (ED), were included. A biochemical urine analysis using gas chromatography‐tandem mass spectrometry was performed. Out of 100 patients, 86 received antihypertensives. Urine analyses could be evaluated unambiguously in 62 patients. In 15 of these 62 patients (24%), a nonadherence could be demonstrated, and in 21 patients (34%), a partial nonadherence could be demonstrated. Patients with nonadherence or partial nonadherence showed a longer hypertension history (15[5‐22] vs 10[3‐15] years, P = 0.04) were prescribed more general medication (number 7.1 ± 3.4 vs 3.4 ± 1.8; P
Databáze: OpenAIRE
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