Psychiatric diagnoses underlying the phenocopy syndrome of behavioural variant frontotemporal dementia
| Autor: | M. L. Stek, B. J. Kerklaan, Welmoed A. Krudop, C. J. Kerssens, Yolande A.L. Pijnenburg, Philip Scheltens, Flora Gossink, Annemiek Dols |
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| Přispěvatelé: | Amsterdam Neuroscience - Neurodegeneration, Neurology, Psychiatry, EMGO - Mental health |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Neuroimaging Neuropsychological Tests medicine Humans Functional decline Relationship problems Psychiatry Clinical syndrome Aged Retrospective Studies Neurologic Examination Phenocopy Mental Disorders Syndrome Middle Aged medicine.disease Magnetic Resonance Imaging Psychological evaluation Psychiatry and Mental health Frontotemporal Dementia Psychiatric diagnosis Disease Progression Female Surgery Neurology (clinical) Psychology Personality Frontotemporal dementia |
| Zdroj: | Gossink, F T, Dols, A, Kerssens, C J, Krudop, W A, Kerklaan, B J, Scheltens, P, Stek, M L & Pijnenburg, Y A L 2016, ' Psychiatric diagnoses underlying the phenocopy syndrome of behavioural variant frontotemporal dementia ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 87, no. 1, pp. 64-68 . https://doi.org/10.1136/jnnp-2014-308284 Journal of Neurology, Neurosurgery and Psychiatry, 87(1), 64-68. BMJ Publishing Group |
| ISSN: | 0022-3050 |
| Popis: | Introduction The frontotemporal dementia (FTD) consortium criteria (2011) emphasise the importance of distinguishing possible and probable behavioural variant FTD (bvFTD). A significant number of possible patients with bvFTD do not show functional decline and remain with normal neuroimaging over time, thus exhibiting the bvFTD phenocopy syndrome. A neurodegenerative nature is unlikely but an alternative explanation is missing. Our aim was to detect psychiatric conditions underlying the bvFTD phenocopy syndrome after extensive evaluation. Methods We included patients with the bvFTD phenocopy syndrome whereby patients with probable bvFTD served as a control group. Patients had to have undergone both neurological and psychiatric evaluation. Their charts were reviewed retrospectively. Using both qualitative and quantitative methods, psychiatric and psychological conditions associated with the clinical syndrome were determined in both groups and their relative frequencies were compared. Results Of 181 suspected bvFTD cases, 33 patients with bvFTD phenocopy syndrome and 19 with probable bvFTD were included. Recent life events, relationship problems and cluster C personality traits were the most prevalent psychiatric/psychological conditions. The frequency of these conditions was higher in the group of patients with the bvFTD phenocopy syndrome (n=28) compared to the probable bvFTD group (n=9) (χ2 p |
| Databáze: | OpenAIRE |
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