An in situ-forming zwitterionic hydrogel as vitreous substitute
| Autor: | Bin Wang, Yanbin Huang, Yong Tao, Jing Chang, Hong Xu, Bao-hua Guo, Yan-rong Jiang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Materials science Biocompatibility technology industry and agriculture Biomedical Engineering macromolecular substances General Chemistry General Medicine Polymer chemistry.chemical_compound Monomer chemistry Cystamine Polymer chemistry Self-healing hydrogels Copolymer medicine Methacrylamide General Materials Science Swelling medicine.symptom |
| Zdroj: | Journal of materials chemistry. B. 3(6) |
| ISSN: | 2050-7518 |
| Popis: | Zwitterionic polymers have shown ultra-low biofouling properties at surfaces and excellent biocompatibility as implant. In this study, an in situ-forming zwitterionic hydrogel was designed and evaluated, both in vitro and in vivo, as a long-term vitreous substitute. The zwitterionic polymer poly(MPDSA-co-AC) was designed as a copolymer of the sulfobetaine methacrylamide and acryloyl cystamine monomers, providing the zwitterionic components and the thiol functional groups, respectively. The in situ gelation was via the thiol-ene Michael addition reaction with α-PEG-MA as the crosslinker. The gelation time, rheological properties, swelling profiles, and the transparency of zwitterionic hydrogels were studied in detail. Two systems with different crosslinker concentrations were tested in a rabbit model, and the one with the thiol-ene ratio of 2 : 1 showed excellent biocompatibility in vivo, formed space-filling hydrogels and remained transparent in the vitreous cavity for the 2 month implantation period. Therefore, in situ-forming zwitterionic hydrogels represent a promising material system as a vitreous substitute and possibly for other soft tissue replacements. |
| Databáze: | OpenAIRE |
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