Temporal development of neurochemical and cognitive impairments following reserpine administration in rats
| Autor: | Alexandra Latini, Lucila de Bortoli da Silva, Geison S. Izídio, Guilherme Pasetto Fadanni, Aline Guimarães Pereira, Anicleto Poli, Rui Daniel Prediger, Filipe C. Matheus |
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| Rok vydání: | 2020 |
| Předmět: |
Serotonin
medicine.medical_specialty Reserpine Time Factors Parkinson's disease Dopamine Prefrontal Cortex Hippocampus Striatum 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Neurochemical Memory Internal medicine medicine Animals Cognitive Dysfunction Prefrontal cortex 030304 developmental biology 0303 health sciences Adrenergic Uptake Inhibitors Behavior Animal business.industry Parkinson Disease Recognition Psychology medicine.disease Corpus Striatum Rats Disease Models Animal Memory Short-Term Endocrinology Systemic administration business Locomotion 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Behavioural Brain Research. 383:112517 |
| ISSN: | 0166-4328 |
| Popis: | The systemic administration of low reserpine (RES) doses (0.1–1.0 mg/kg) has been proposed as a valuable rat model for the study of non-motor symptoms of Parkinson’s disease (PD). Here, we investigated the temporal-dependent effects of RES (1 mg/kg, s.c.) on short-term memory and locomotion, as well as, the levels of dopamine, serotonin and its metabolites in the striatum, hippocampus and prefrontal cortex at 3, 24 or 72 h after RES administration. RES administrations resulted in social and object recognition memory impairment and increased dopamine turnover in the striatum, without changes in the rat spontaneous locomotor activity, 3 h after RES administration. Altogether, these results provide new insights for the use of RES administration as an experimental design for the study of PD non-motor symptoms in rats. |
| Databáze: | OpenAIRE |
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