Prognostic Value of MRS Metabolites in Postoperative Irradiated High Grade Gliomas
| Autor: | John Kouvaris, Ioannis Kokakis, Vasileios Kouloulias, Maria Tolia, Matilda Papathanasiou, Dimitrios Verganelakis, Nikolaos Kelekis, George Kyrgias, Eftichia Mosa, George Pissakas, Nikolaos Tsoukalas, Kyriaki Pistevou-Gombaki |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Magnetic Resonance Spectroscopy Every Six Months Article Subject medicine.medical_treatment Urology lcsh:Medicine Creatine Disease-Free Survival General Biochemistry Genetics and Molecular Biology Choline chemistry.chemical_compound Glioma Maximum difference medicine Humans Postoperative Period Aged Temozolomide General Immunology and Microbiology medicine.diagnostic_test business.industry lcsh:R Age Factors Magnetic resonance imaging General Medicine Middle Aged Prognosis medicine.disease Magnetic Resonance Imaging Radiation therapy chemistry Female Neoplasm Grading Neoplasm Recurrence Local Nuclear medicine business Research Article medicine.drug |
| Zdroj: | BioMed Research International, Vol 2015 (2015) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Purpose. We studied the prognostic significance of Magnetic Resonance Spectroscopy (MRS) in operated high grade gliomas.Materials and Methods. Twelve patients were treated with radiotherapy and Temozolomide. The MRS data were taken four weeks after operation (before radiotherapy) and every six months after the completion of RT. The N-acetyl aspartate, choline, creatine, and myo-inositol parameters were quantified, analyzed, and correlated to recurrence-free survival (RFS).Results. The median RFS was 26.06 months. RFS was significantly worse in elderly patients(P=0.001)along with the higher choline/creatine ratios at either baseline(P= 0.003)or six months post Radiotherapy(P=0.042). Median RFS was 23 months in high choline/creatine levels ≥2 at 6 months after radiotherapy and 11 months for those with P=0.045).Conclusion. Age and choline/creatine ratio are strong independent prognostic factors in high grade gliomas. |
| Databáze: | OpenAIRE |
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