Treatment of chytridiomycosis with reduced-dose itraconazole
| Autor: | David Paddock, Jack L. Allen, Mark D. Schrenzel, Allan P. Pessier, Megan E. B. Jones, Lee Bender |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Wyoming
Amphibian Veterinary medicine Antifungal Agents Itraconazole Aquatic Science Polymerase Chain Reaction Disease Outbreaks biology.animal medicine Animals Chytridiomycosis Ecology Evolution Behavior and Systematics biology Ecology Anaxyrus baxteri Outbreak Litoria caerulea biology.organism_classification Reduced dose Wyoming toad Chytridiomycota Mycoses Anura medicine.drug |
| Zdroj: | Diseases of Aquatic Organisms. 99:243-249 |
| ISSN: | 1616-1580 0177-5103 |
| Popis: | Effective treatment methods to eliminate infection with Batrachochytrium dendroba- tidis (Bd) are required for development of sustainable captive survival assurance populations of amphibians and to reduce the risk of introducing Bd to new locations as part of amphibian trade or reintroduction programs. Treatment with itraconazole baths at 100 mg l �1 is commonly used in captive amphibians, but side effects are observed in some amphibian species and life stages. Nat- urally occurring outbreaks of chytridiomycosis in Wyoming toads Anaxyrus baxteri and White's tree frogs Litoria caerulea were treated with lower-dose itraconazole baths (e.g. 50 mg l �1 for White's tree frogs) and followed post-treatment with serial Taqman PCR testing to confirm elimi- nation of Bd infection. Post-treatment PCR tests were consistently negative for the presence of Bd and treatment was deemed successful. Although this was not a controlled clinical trial, results sug- gest that lower doses of itraconazole may be effective for treatment of chytridiomycosis with resulting cost savings to amphibian conservation programs and a potential for a reduction in dose- related side effects from itraconazole treatment. Prospective clinical trials of alternative itracona- zole treatment protocols are encouraged. |
| Databáze: | OpenAIRE |
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