Clinical characteristics of 3062 COVID‐19 patients: A meta‐analysis
| Autor: | Pan Ji, Hongyuan Li, Chunling Zhao, Jianfeng Zhang, Jielong Pang, Zhimei Zhong, Cuiying He, Jieyun Zhu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Abdominal pain Gastroenterology 0302 clinical medicine Case fatality rate 030212 general & internal medicine Leukocytosis Child Lung Research Articles Fatigue Aged 80 and over Coronavirus disease 2019 Middle Aged C-Reactive Protein Infectious Diseases Vomiting 030211 gastroenterology & hepatology Female medicine.symptom Respiratory Insufficiency Research Article Adult Diarrhea medicine.medical_specialty Adolescent Fever Nausea Pneumonia Viral Asymptomatic 03 medical and health sciences Young Adult Internal medicine Virology medicine Humans Pandemics Aged Clinical characteristics business.industry SARS-CoV-2 COVID-19 Pneumonia Respiratory failure Cough Meta‐analysis Liver function business Systematical review |
| Zdroj: | Journal of Medical Virology |
| ISSN: | 1096-9071 0146-6615 |
| DOI: | 10.1002/jmv.25884 |
| Popis: | Objective We aim to systematically review the clinical characteristics of Coronavirus disease 2019 (COVID‐19). Methods Seven datebases were searched to collect studies about the clinical characteristics of COVID‐19 from 1 January 2020 to 28 February 2020. Then, meta‐analysis was performed by using Stata12.0 software. Results A total of 38 studies involving 3 062 COVID‐19 patients were included. Meta‐analysis showed that a higher proportion of infected patients were male (56.9%). The incidence rate of respiratory failure or ARDS was 19.5% and the fatality rate was 5.5%. Fever (80.4%), fatigue (46%), cough (63.1%) and expectoration (41.8%) were the most common clinical manifestations. Other common symptoms included muscle soreness (33%), anorexia (38.8%), chest tightness (35.7%), shortness of breath (35%), dyspnea (33.9%). Minor symptoms included nausea and vomiting (10.2%), diarrhea (12.9%), headache (15.4%), pharyngalgia(13.1%), shivering (10.9%) and abdominal pain (4.4%). Patients with asymptomatic was 11.9%. Normal leukocytes counts (69.7%), lymphopenia (56.5%), elevated C‐reactive protein levels (73.6%), elevated ESR (65.6%) and oxygenation index decreased (63.6%) were observed in most patients. About 37.2% of patients with elevated D‐dimer, 25.9% of patients with leukopenia, along with abnormal levels of liver function (29%) and renal function (25.5%). Other findings included leukocytosis (12.6%) and elevated procalcitonin (17.5%). Only 25.8% of patients had lesions involving single lung and 75.7% of patients had lesions involving bilateral lungs. Conclusions The most commonly experienced symptoms of COVID‐19 patients were fever, fatigue, cough and expectoration. A relatively small percentage of patients were asymptomatic. Most patients showed normal leucocytes counts, lymphopenia, elevated levels of C‐reactive protein and ESR. Bilateral lungs involvement was common. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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