Characterization of Viable and Nonviable Myocardium at MR Imaging: Comparison of Gadolinium-based Extracellular and Blood Pool Contrast Materials versus Manganese-based Contrast Materials in a Rat Myocardial Infarction Model
| Autor: | I. Kofi Adzamli, James H. Wible, M. Peri Periasamy, Max D. Adams, Jon M. Chia, Sebastian Flacke, John S. Allen, Christine H. Lorenz |
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| Rok vydání: | 2003 |
| Předmět: |
Male
media_common.quotation_subject Gadolinium Myocardial Infarction Contrast Media chemistry.chemical_element Infarction Manganese Rats Sprague-Dawley Flip angle Organometallic Compounds Extracellular medicine Animals Contrast (vision) Radiology Nuclear Medicine and imaging Myocardial infarction media_common Analysis of Variance medicine.diagnostic_test Phantoms Imaging business.industry Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Rats Disease Models Animal Manganese Compounds chemistry business Nuclear medicine |
| Zdroj: | Radiology. 226:731-738 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiol.2263020151 |
| Popis: | To determine the contrast agent behavior of gadolinium-based (extracellular and albumin-binding) and manganese-based contrast media for late-enhancement imaging of myocardial infarction.Coronary ligation was performed in 30 rats, and they were serially imaged with segmented inversion-recovery gradient-echo magnetic resonance (MR) imaging (repetition time msec/echo time msec/inversion time msec [fixed], 5.2/2.5/430; flip angle, 15 degrees ) during 1 hour after administration of contrast media by using a 1.5-T MR unit. Serial measurements of the longitudinal relaxation were performed by using the Look-Locker approach (repetition time msec/echo time msec, 1,000/3.5; flip angle, 10 degrees ). Detection and size of infarction were evaluated at each time point and compared with end-point histologic findings.For all manganese-based media, the contrast agent cleared from the blood pool rapidly. Manganese-based contrast media allowed precise labeling of viable cardiomyocytes within 30 minutes, and the labeling persisted for at least 1 hour. Accumulation of gadoversetamide in the infarct area was apparent after 5 minutes, and the peak contrast-to-noise ratio (CNR) between infarct and myocardium was comparable to the peak CNR of manganese-based contrast agents. Extracellular gadopentetate dimeglumine provided excellent infarct detection but a small imaging window for precise sizing of the infarct if a fixed inversion time of 430 msec was used. Albumin-binding gadolinium-based contrast media provided a longer imaging window, but infarct size was overestimated because of the nonspecific distribution of the unbound gadolinium agent.When extracellular gadolinium-based agents are used for infarct size measurement, imaging parameters and timing are important because the kinetics of both normal and irreversibly injured myocardium must be considered. Manganese-based agents are highly specific and less sensitive to timing for infarct size determination, but further studies are required to determine if they are feasible for human use. |
| Databáze: | OpenAIRE |
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