RETINAL PATHOLOGIC CHANGES IN MULTIPLE SCLEROSIS
| Autor: | Flynn T, John B. Kerrison, Green Wr |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Retinal Ganglion Cells Pathology medicine.medical_specialty Multiple Sclerosis Optic Disk Nerve fiber Retina chemistry.chemical_compound Nerve Fibers Atrophy Retinal Diseases medicine Humans Aged Neuromyelitis optica business.industry Multiple sclerosis Optic Nerve Uveitis Posterior Retinal General Medicine Middle Aged medicine.disease Retinal Vein eye diseases Ganglion Ophthalmology medicine.anatomical_structure chemistry Optic nerve Female sense organs Phlebitis business |
| Zdroj: | Retina. 14:445-451 |
| ISSN: | 0275-004X |
| DOI: | 10.1097/00006982-199414050-00010 |
| Popis: | Purpose To describe the ocular pathologic changes in multiple sclerosis (MS), with attention to its effects on the uveal tract and retinal veins. Methods Cases of 26 patients with MS and 3 patients with neuromyelitis optica were reviewed; retinal trypsin digestion was performed on remaining wet tissue for 20 of these patients. Eyes were specifically examined for inflammation of the retinal vessels, uveal tract, retina, optic nerve, and pars plana. Specimens were also examined for atrophy of the optic nerve, ganglion cell, and nerve fiber layers. Results Atrophy of the nerve fiber and ganglion cell layers was present in 73% of the cases with MS and correlated with optic nerve atrophy; choroiditis was present in 11.5%; bilateral cyclitis without other foci of inflammation was present in 1 case; and retinal phlebitis was present in 20% (most of which were only identified after trypsin digestion). Optic nerve inflammation was present in two of the patients with neuromyelitis optica. Conclusion Uveitis and retinal phlebitis are manifestations of MS. Trypsin digestion with microscopic examination is a sensitive method of testing for phlebitis, which may explain why the frequency found in this series is higher than in others. These lesions are similar to the perivenular cuffing that occurs in the central nervous system in MS. |
| Databáze: | OpenAIRE |
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