Case studies on genetically modified organisms (GMOs): Potential risk scenarios and associated health indicators

Autor: Gijs Kleter, Marzia De Giacomo, Eefke Weesendorp, Ralf Einspanier, Carlo Brera, R. Onori, Jeroen P. van Dijk, Jan van der Meulen, Norbert Stockhofe, Esther J. Kok, J.-M. Wal, Jean-Paul Lallès, Barbara De Santis, Paul Bikker
Přispěvatelé: Istituto Superiore di Sanità, Wageningen University and Research Centre (WUR), Service de Pharmacologie et d'Immunoanalyse (SPI), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Unité de gestion du département alimentation humaine, Institut National de la Recherche Agronomique (INRA), RIKILT, Wageningen University and Research [Wageningen] (WUR), Freie Universität Berlin, Livestock Research, European Project: 312031,EC:FP7:KBBE,FP7-KBBE-2012-6-singlestage,MARLON(2012), Istituto Superiore di Sanità (ISS), Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Rok vydání: 2017
Předmět:
0301 basic medicine
Health indicators
Novel Foods & Agrochains
Animal Nutrition
Toxicology
Novel Foods & Agroketens
Health data
Diagnostics & Crisis Organization
BU Toxicology
Novel Foods & Agrochains
2. Zero hunger
Animal health
Diagnostiek & Crisisorganisatie
BU Toxicology
Bacteriologie
Bacteriology
Host Pathogen Interaction & Diagnostics
04 agricultural and veterinary sciences
General Medicine
Horizontal gene transfer
Plants
Genetically Modified
Diervoeding
Genetically modified organism
BU Toxicologie
Novel Foods & Agroketens
Allergenicity
Livestock
Corporate Education
Nutritionally altered geneticalli modified crops
Nutritive Value
Food Hypersensitivity
DNA
Plant
Gene Transfer
Horizontal
BU Toxicologie
ANIMAL EXPOSURE
Biology
Risk Assessment
03 medical and health sciences
Research & Innovation
Product Surveillance
Postmarketing
Fusarium toxins
Mycotoxin-reduction
Animals
Humans
European Union
VLAG
Host Pathogen Interaction & Diagnostics
Corporate Education
Research & Innovation
business.industry
Potential risk
0402 animal and dairy science
Bacteriology
Mycotoxins
040201 dairy & animal science
Health indicator
Animal Feed
Host Pathogen Interactie & Diagnostiek
Biotechnology
030104 developmental biology
Bacteriologie
Host Pathogen Interactie & Diagnostiek
WIAS
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Genetically modified -feed
Food Science
Zdroj: Food and Chemical Toxicology
Food and Chemical Toxicology, Elsevier, 2018, 117, pp.36-65. ⟨10.1016/j.fct.2017.08.033⟩
Food and Chemical Toxicology 117 (2018)
Food and Chemical Toxicology, 2018, 117, pp.36-65. ⟨10.1016/j.fct.2017.08.033⟩
Food and Chemical Toxicology, 117, 36-65
ISSN: 1873-6351
0278-6915
Popis: Transparency document related to this article can be found online at http://dx.doi.org/10.1016/j.fct.2017.08.033. Supplementary data related to this article can be found at http://dx.doi.org/10.1016/j.fct.2017.08.033.; International audience; Within the frame of the EU-funded MARLON project, background data were reviewed to explore the possibility of measuring health indicators during post-market monitoring for potential effects of feeds, particularly genetically modified (GM) feeds, on livestock animal health, if applicable. Four case studies (CSs) of potential health effects on livestock were framed and the current knowledge of a possible effect of GM feed was reviewed. Concerning allergenicity (CS-1), there are no case-reports of allergic reactions or immunotoxic effects resulting from GM feed consumption as compared with non-GM feed. The likelihood of horizontal gene transfer (HGT; CS-2) of GMO-related DNA to different species is not different from that for other DNA and is unlikely to raise health concerns. Concerning mycotoxins (CS-3), insect-resistant GM maize may reduce fumonisins contamination as a health benefit, yet other Fusarium toxins and aflatoxins show inconclusive results. For nutritionally altered crops (CS-4), the genetic modifications applied lead to compositional changes which require special considerations of their nutritional impacts. No health indicators were thus identified except for possible beneficial impacts of reduced mycotoxins and nutritional enhancement. More generally, veterinary health data should ideally be linked with animal exposure information so as to be able to establish cause-effect relationships.
Databáze: OpenAIRE
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