Susac syndrome complicating a SARS-CoV-2 infection
| Autor: | Emmanuel D'Heygere, Dorien Herijgers, Simon D'hulst, Evelien Vancaester, Vincent Raymaekers, Annelies Fabry, Julie Dutoit, Johanna Vercammen, Patrick Vanderdonckt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Neurology Susac Syndrome Snowball-like lesion Encephalopathy Case Report Cellular and Molecular Neuroscience Virology medicine Humans Stroke Pandemics business.industry SARS-CoV-2 COVID-19 medicine.disease Magnetic Resonance Imaging Hyperintensity Sensorineural hearing loss Rituximab Neurology (clinical) Splenial business medicine.drug |
| Zdroj: | Journal of Neurovirology |
| ISSN: | 1538-2443 1355-0284 |
| Popis: | In 2020 the world was captivated by the COVID-19 pandemic. Current scientific evidence suggests an interaction of SARS-CoV-2 and the human immune system. Multiple cases were reported of patients with COVID-19 presenting with encephalopathy, confusion or agitation, stroke, and other neurologic symptoms. We present a case of a 40-year-old man diagnosed with Susac syndrome after COVID-19, presenting with acute sensorineural hearing loss, encephalopathy, a splenial "snowball-like" lesion, and branch retinal artery occlusions with distal arterial wall hyperintensity. Although the pathophysiology of Susac syndrome remains unclear, this case is in line with the ongoing debate about the influence of SARS-CoV-2 on the human immune system. Corticosteroid treatment was initiated, followed by two treatments with rituximab, with clinical improvement of the symptomatology. Maintenance treatment currently consists of mycophenolic acid (MPA). Future research will need to focus on the underlying mechanisms for COVID-19-associated (autoimmune) complications. |
| Databáze: | OpenAIRE |
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