Primary hyperparathyroidism: iliac crest cortical thickness, structure, and remodeling evaluated by histomorphometric methods
| Autor: | Peer Christiansen, Torben Steiniche, H. Brockstedt, F. Melsen, Lis Mosekilde, Ib Hessov |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Histology Bone density Adolescent Physiology Endocrinology Diabetes and Metabolism Iliac crest Bone remodeling Ilium Cortical porosity Group (periodic table) Bone Density Internal medicine Medicine Humans Aged Hyperparathyroidism business.industry Anatomy Middle Aged medicine.disease Biomechanical Phenomena Apposition Endocrinology medicine.anatomical_structure Cortical bone Female Bone Remodeling business Primary hyperparathyroidism Biomarkers |
| Zdroj: | Christiansen, P, Steiniche, T, Brockstedt, H, Mosekilde, L, Hessov, I & Melsen, F 1993, ' Primary hyperparathyroidism : Iliac crest cortical thickness, structure and remodeling evaluated by histomorphometric methods ', Bone, vol. 14, no. 3, pp. 403-408 . https://doi.org/10.1016/8756-3282(93)90171-6 |
| ISSN: | 8756-3282 |
| Popis: | Iliac crest bone biopsies from 62 patients (42 women, 20 men; median age 59 years; range 17-79 years) with primary hyperparathyroidism (PHP) were examined. Static and structural parameters were compared with 30 age- and sex-matched normal controls. Eighteen sex-matched younger controls were used for evaluation of the dynamic controls. On the endocortical surface increase in extension of eroded (p < 0.01) and formative (p < 0.01) surfaces was found in PHPs compared with normals. Endocortical bone formation rate was increased in PHPs (p < 0.05), but mineral appositional rate and adjusted appositional rate were normal. On the periosteal surface very little remodeling activity was found. Although bone formation rate was found increased in PHPs (p < 0.05), more than half of the labeled biopsies were without periosteal tetracycline in patients, and only 2 of 18 biopsies from normals contained periosteal tetracycline labels. No significant decreases in cortical width or relative cortical width were found in PHPs. In both patients and controls an age-related decrease in relative cortical width cortical width were found in PHPs. In both patients and controls an age-related decrease in relative cortical width was noted for women (PHPs: r = -0.52, p < 0.01; controls: r = -0.59, p < 0.001), but not for men. Cortical porosity was about 30% increased in PHPs (p < 0.02). Only normal women showed a positive age-related increase in porosity (r = 0.61, p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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