Eplerenone inhibits atherosclerosis in nonhuman primates
| Autor: | Hiroshi Sakonjo, Mizuo Miyazaki, Michiko Muramatsu, Kazuyoshi Kirimura, Shinji Takai, Denan Jin |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Normal diet medicine.drug_class Biology Peptidyl-Dipeptidase A Spironolactone Cholesterol Dietary chemistry.chemical_compound Mineralocorticoid receptor Internal medicine Malondialdehyde Renin–angiotensin system Renin Internal Medicine medicine Animals Aorta Chemokine CCL2 Ultrasonography Aldosterone Dose-Response Relationship Drug Cholesterol Cholesterol HDL Cholesterol LDL Atherosclerosis Lipid Metabolism Acetylcholine Eplerenone Lipoproteins LDL Vasodilation Macaca fascicularis Endocrinology medicine.anatomical_structure Carotid Arteries chemistry Mineralocorticoid Tunica Intima medicine.drug |
| Zdroj: | Hypertension (Dallas, Tex. : 1979). 46(5) |
| ISSN: | 1524-4563 |
| Popis: | Aldosterone may be involved in the pathogenesis of atherosclerosis. We investigated the effect of eplerenone, a selective mineralocorticoid receptor blocker, on atherosclerosis in monkeys fed a high-cholesterol diet. Monkeys fed a high-cholesterol diet for 9 months were divided into 3 groups: those treated with a low dose of eplerenone (30 mg/kg per day); those treated with a high dose of eplerenone (60 mg/kg per day); and the placebo-treated group. The normal group consisted of monkeys fed a normal diet. There were no significant differences in blood pressure and cholesterol levels between the placebo- and eplerenone-treated groups. On the other hand, monocyte chemoattractant protein-1 and malondialdehyde-modified LDL were significantly higher in the placebo-treated group than in the normal group, whereas they were suppressed in the eplerenone-treated groups. The ratio of intimal volume to total volume by intravascular ultrasound analysis imaging of the aortas was dose-dependently lower in the eplerenone-treated groups than in the placebo-treated group. Acetylcholine-induced vasorelaxation was significantly weaker in the placebo-treated group than in the normal group, but the vasorelaxation was strengthened in the eplerenone-treated groups. A significant upregulation of angiotensin-converting enzyme activity was observed in the placebo-treated group, but the activity was suppressed in the eplerenone-treated groups. In conclusion, eplerenone may strengthen the endothelium-dependent relaxation and suppress angiotensin-converting enzyme activity in the vasculature, thus preventing the development of atherosclerosis in nonhuman primates. |
| Databáze: | OpenAIRE |
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