The role of central CB2 cannabinoid receptors on food intake in neonatal chicks
Autor: | E Hosseini Amir Abad, Ladan Emadi, H. Jonaidi |
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Rok vydání: | 2011 |
Předmět: |
Male
Agonist medicine.medical_specialty Indoles Time Factors Cannabinoid receptor Corticotropin-Releasing Hormone Physiology medicine.drug_class medicine.medical_treatment Biology Receptor Cannabinoid CB2 Eating Behavioral Neuroscience Immune system Internal medicine medicine Cannabinoid receptor type 2 Animals Receptor Ecology Evolution Behavior and Systematics Injections Intraventricular Antagonist Brain Feeding Behavior Endocannabinoid system Peptide Fragments Endocrinology Animals Newborn lipids (amino acids peptides and proteins) Animal Science and Zoology Cannabinoid Chickens |
Zdroj: | Journal of Comparative Physiology A. 197:1143-1147 |
ISSN: | 1432-1351 0340-7594 |
Popis: | The endocannabinoids (ECBs) have diverse physiological functions including the regulation of food intake and metabolism. In mammals, ECBs regulate feeding primarily through the CB1 receptors within the brain whereas the CB2 receptors are primarily involved in the regulation of immune function by direct action on peripheral immune cells and central glia. The central effect of ECBs on feeding behavior has not been studied in non-mammalian species. Therefore, the present study investigated the effect of CB65, a selective CB2 receptors agonist, on food intake in the neonatal chicks. In addition, the effect of astressin, a CRF receptor antagonist, on CB65-induced food intake was also investigated. Intracerebroventricular injection of the CB65 (1.25 μg) increased the food intake at 30- and 60-min post-injection significantly as compared to the control group. Pretreatment with a selective CB2 receptor antagonist, AM630, but not astressin, significantly attenuated the CB65-induced food intake. These results suggested that CB2 receptor agonists act on the brain to induce food intake. |
Databáze: | OpenAIRE |
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