Combined vitrectomy, near-confluent panretinal endolaser, bevacizumab and cyclophotocoagulation for neovascular glaucoma — a retrospective interventional case series

Autor: Winfried Göbel, Jost Hillenkamp, Piotr Strzalkowski, Alicja Strzalkowska, Nils A. Loewen
Rok vydání: 2020
Předmět:
Male
Pars plana
0301 basic medicine
medicine.medical_specialty
Intraocular pressure
Visual acuity
genetic structures
medicine.medical_treatment
viruses
Visual Acuity
Vitrectomy
Antibodies
Monoclonal
Humanized
Neovascular glaucoma
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Ophthalmology
Humans
Medicine
General Pharmacology
Toxicology and Pharmaceutics
Aged
Retrospective Studies
Aged
80 and over
Glaucoma medication
General Immunology and Microbiology
business.industry
Articles
Diabetic retinopathy
General Medicine
Middle Aged
Cataract surgery
biochemical phenomena
metabolism
and nutrition
medicine.disease
eye diseases
Bevacizumab
Glaucoma
Neovascular
medicine.anatomical_structure
030104 developmental biology
integrative surgical approach
030221 ophthalmology & optometry
iris neovascularization
Female
Ocular ischemic syndrome
sense organs
medicine.symptom
business
Research Article
Zdroj: F1000Research
ISSN: 2046-1402
Popis: Background: Neovascular glaucoma (NVG) is a severe, potentially blinding disease and a therapeutic challenge. The purpose of this study was to evaluate the safety and efficacy of an integrative surgical approach to neovascular glaucoma. Methods: Retrospective analysis of a one-year follow-up of a consecutive interventional case series of NVG. Eyes underwent transscleral cyclophotocoagulation, pars plana vitrectomy, near-confluent panretinal photocoagulation, and intravitreal bevacizumab. Phakic eyes underwent concomitant cataract surgery. Best-corrected visual acuity (BCVA, logMAR), intraocular pressure (IOP, mmHg), number of glaucoma medication, visual analog pain scale (VAPS, 0-10) were recorded at baseline, and 1, 3, 6, and 12 months. Blind eyes were excluded. Results: Seventy-seven eyes of 77 patients (45 male, 32 female, mean age 73.6±12.2 years) were included. NVG underlying conditions included retinal vein occlusion (41.6%), proliferative diabetic retinopathy (35.1%), central retinal artery occlusion (19.5%), and ocular ischemic syndrome (3.9%). Mean IOP decreased postoperatively from 46.3±10.1 mmHg to 14.5±7.9 mmHg (p Conclusions: A single, comprehensive surgery session lowered IOP significantly, reduced GMS, and controlled pain.
Databáze: OpenAIRE
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