Immunogenicity of a DNA prime and recombinant adenovirus boost regime significantly varies between rhesus macaques of Chinese and Indian origins
| Autor: | Ki Seok Park, Gerhard Hunsmann, Monika Franz, So-Shin Ahn, You Suk Suh, Young Chul Sung, Kwang Soon Kim, Reiner Schulte, Christiane Stahl-Hennig, Nicole Stolte-Leeb, Ulrike Sauermann |
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| Rok vydání: | 2007 |
| Předmět: |
China
viruses T-Lymphocytes Simian Acquired Immunodeficiency Syndrome India Enzyme-Linked Immunosorbent Assay medicine.disease_cause Antibodies Viral Statistics Nonparametric law.invention Interferon-gamma Immune system Acquired immunodeficiency syndrome (AIDS) law Neutralization Tests medicine Vaccines DNA Animals Cell Proliferation Vaccines Synthetic General Veterinary biology Immunogenicity SAIDS Vaccines virus diseases Simian immunodeficiency virus biology.organism_classification medicine.disease Virology Macaca mulatta Rhesus macaque Disease Models Animal Immunization Area Under Curve Immunology Recombinant DNA Animal Science and Zoology Simian Immunodeficiency Virus Viral load |
| Zdroj: | Journal of medical primatology. 36(4-5) |
| ISSN: | 0047-2565 1600-0684 |
| Popis: | Background Due to an ever increasing shortage of rhesus macaques ofIndian origin (InR) that have been generally used for preclinical AIDS vac-cine trials in non-human primates, demand is rising for Chinese rhesusmacaques (ChR). However, the immunogenicity of an AIDS vaccine candi-date has not been compared in parallel in both rhesus macaque subspecies.Methods ChR and InR were immunized with SIV/HIV DNA andadenovirus vaccine and their immune responses to SIV and HIV evaluated.Results SIV Gag- and Env-specific T-cell responses and SIV-specificlymphoproliferative responses measured in ChR were significantly weakerthan those in InR (P < 0.05). By contrast, antibody responses to SIV Env,Tat, and Nef in ChR were stronger than those in InR (P < 0.05).Conclusions Immunogenicity of an AIDS vaccine can vary significantlydepending on the geographic origin implying genetic differences of maca-ques. This must be considered when describing and interpreting results ofsuch vaccine studies. J Med Primatol doi:10.1111/j.1600-0684.2007.00237.x |
| Databáze: | OpenAIRE |
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