| Popis: |
Some 50 years ago, Goldberger and Anderson 1 demonstrated the susceptibility of macaque monkeys to measles infection. Other workers subsequently confirmed and extended these observations. 2,3 Simians played a key role in early studies, since they represented the only known host, other than man, useful as an indicator system for this agent. Investigations were plagued, however, by the unpredictable resistance of some monkeys to the measles virus. 4 The explanation for much of this difficulty was furnished by Enders and his associates 5 in 1956, when, using modern techniques unavailable to workers of the preceding decades, they showed that 22 of 24 apparently healthy laboratory macaques possessed detectable complement fixing antibodies for measles. In contrast, sera from 21 cynomolgus monkeys bled in the Philippines and an additional 10 newly arrived in Boston from Malaya were devoid of measles antibodies. Ruckle, 6 in a separate study during this period, found that |
