Ventricular-arterial coupling in centenarians without cardiovascular diseases
| Autor: | Luigi Padeletti, Andrea Sonaglioni, Carmen Sommese, Massimo Baravelli, Claudio Anzà, Michele Lombardo, Jonathan A. Kirk |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Aging medicine.medical_specialty Population Myocardial stiffness Blood Pressure 030204 cardiovascular system & hematology Ventricular Function Left 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans education Inverse correlation Ventricular arterial coupling Body surface area Aged 80 and over education.field_of_study Sex Characteristics business.industry Arteries medicine.anatomical_structure Blood pressure Ventricle Echocardiography Cardiology Female Geriatrics and Gerontology business Wall thickness 030217 neurology & neurosurgery |
| Zdroj: | Aging clinical and experimental research. 30(4) |
| ISSN: | 1720-8319 |
| Popis: | Ventricular-arterial (VA) coupling is a central determinant of cardiovascular system performance and cardiac energetics. This index is expressed by the Ea/Ees ratio, where the effective arterial elastance (Ea) indicates the net arterial load exerted on the left ventricle and the left ventricular end-systolic elastance (Ees) is a load-independent measure of left ventricular chamber performance. Thirty-three centenarians (100.6 ± 1.2 years, range 99–105 years, 10 M) without cardiovascular diseases underwent a complete echocardiographic evaluation and an instantaneous arterial blood pressure measurement, to characterize the Ea/Ees ratio and its two determinants indexed to body surface area. VA coupling was markedly reduced (Ea/Ees ratio 0.40 ± 0.1), reflecting a disproportionate increase in Ees index (8.5 ± 2.2 mmHg/ml/m2) compared with Ea index (3.2 ± 0.8 mmHg/ml/m2). Notably, the coupling ratio was significantly lower in women (0.37 ± 0.1) than in men (0.45 ± 0.1, p = 0.0003), due to an increase in Ees index significantly greater in women (9.4 ± 1.9 mmHg/ml/m2) than in men (6.5 ± 1.5 mmHg/ml/m2, p = 0.0002). Using multivariate regression analysis, only female gender (β coefficient −0.04, p = 0.01) and relative wall thickness (β coefficient −0.49, p |
| Databáze: | OpenAIRE |
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