Effect of Length of a Ryanodine-treated Muscle on Oxygen Uptake

Autor:	Leslie E. Edwards, Marie-Louise Flinker
Rok vydání:	1950
Předmět:	medicine.medical_specialty Ryanodine Chemistry Ryanodine receptor Muscles chemistry.chemical_element Oxygen Oxygen uptake General Biochemistry Genetics and Molecular Biology Endocrinology Biochemistry Internal medicine medicine Humans
Zdroj:	Experimental Biology and Medicine. 75:93-96
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-75-18111
Popis:	ConclusionsRyanodine causes a high oxygen consumption in muscles which do not shorten. In those muscles that shorten the oxygen consumption falls off as the muscle shortens. The length of the muscle seems to regulate the oxygen consumption of the Ryanodine-treated muscle. Complete cutting off of the extra metabolism due to Ryanodine occurs at 30% of the rest length.We are indebted to Dr. Roeder and to Merck and Co. for supplying us with the purified Ryanodine powder.We wish to thank Dr. Robert W. Ramsey for his helpful advice and interest in this problem. We are also indebted to him for making many of the microscopic observations on the structure of the muscle at the conclusion of the experiments.
Databáze:	OpenAIRE
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